Growth/differentiation factor-15 (GDF-15): from biomarker to novel targetable immune checkpoint

J Wischhusen, I Melero, WH Fridman - Frontiers in Immunology, 2020 - frontiersin.org
Growth/differentiation factor-15 (GDF-15), also named macrophage inhibitory cytokine-1, is a
divergent member of the transforming growth factor β superfamily. While physiological …

Bioengineered bovine papillomavirus L1 protein Virus-like Particle (VLP) vaccines for enhanced induction of CD8 T cell responses through cross-priming

RP Viscidi, T Rowley, I Bossis - International journal of molecular sciences, 2023 - mdpi.com
Safe and effective T cell vaccines are needed for the treatment or prevention of cancers as
well as infectious agents where vaccines for neutralizing antibodies have performed poorly …

[HTML][HTML] N6-methyladenosine RNA methylation regulators contribute to the progression of prostate cancer

Q Wu, X Xie, Y Huang, S Meng, Y Li, H Wang… - Journal of …, 2021 - ncbi.nlm.nih.gov
Prostate cancer (PCa) is one of the most common epithelial malignant tumors and the fifth
leading cause of cancer death in men. An increasing number of studies have demonstrated …

Resistance to androgen deprivation leads to altered metabolism in human and murine prostate cancer cell and tumor models

J Sun, RA Bok, J DeLos Santos, D Upadhyay… - Metabolites, 2021 - mdpi.com
Currently, no clinical methods reliably predict the development of castration-resistant
prostate cancer (CRPC) that occurs almost universally in men undergoing androgen …

Yin Yang 1 promotes the neuroendocrine differentiation of prostate cancer cells via the non‐canonical WNT pathway (FYN/STAT3)

R Liu, ZP Xu, X Huang, B Xu… - Clinical and Translational …, 2023 - Wiley Online Library
Background A growing number of studies have shown that Yin Yang 1 (YY1) promotes the
development of multiple tumours. The purpose of the current study was to determine the …

Comparative cytotoxic activity of hydroxytyrosol and its semisynthetic lipophilic derivatives in prostate cancer cells

AJ León-González, P Sáez-Martínez… - Antioxidants, 2021 - mdpi.com
A high adherence to a Mediterranean diet has been related to numerous beneficial effects in
human health, including a lower incidence and mortality of prostate cancer (PCa). Olive oil is …

[HTML][HTML] β-Carotene oxygenase 2 genotype modulates the impact of dietary lycopene on gene expression during early TRAMP prostate carcinogenesis

NE Moran, JM Thomas-Ahner, JW Smith, C Silva… - The Journal of …, 2022 - Elsevier
Background Epidemiologic studies suggest lycopene and tomato intake are inversely
associated with human prostate cancer incidence. In the genetically driven murine prostate …

Systemic antioxidant and anti‐inflammatory effects of yellow passion fruit bagasse extract during prostate cancer progression

AM Baseggio, LA Kido, J Viganó… - Journal of Food …, 2022 - Wiley Online Library
We evaluated the impact of yellow passion fruit (Passiflora edulis sp.) bagasse extract
(PFBE) administration in systemic oxidative and inflammatory parameters in vivo …

Systemic Ablation of Camkk2 Impairs Metastatic Colonization and Improves Insulin Sensitivity in TRAMP Mice: Evidence for Cancer Cell-Extrinsic CAMKK2 Functions …

TL Pulliam, D Awad, JJ Han, MM Murray, JJ Ackroyd… - Cells, 2022 - mdpi.com
Despite early studies linking calcium-calmodulin protein kinase kinase 2 (CAMKK2) to
prostate cancer cell migration and invasion, the role of CAMKK2 in metastasis in vivo …

Alzheimer's disease, and breast and prostate cancer research: Translational failures and the importance to monitor outputs and impact of funded research

F Pistollato, C Bernasconi, J McCarthy, I Campia… - Animals, 2020 - mdpi.com
Simple Summary Noncommunicable diseases, such as Alzheimer's disease, and breast and
prostate cancer, are becoming increasingly prevalent in Western countries. To better …