Multiscale simulations of biological membranes: the challenge to understand biological phenomena in a living substance

G Enkavi, M Javanainen, W Kulig, T Róg… - Chemical …, 2019 - ACS Publications
Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

[HTML][HTML] Leveraging knowledge of HDLs major protein ApoA1: Structure, function, mutations, and potential therapeutics

AS Bhale, K Venkataraman - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Abstract Apolipoprotein A1 (ApoA1) is a member of the Apolipoprotein family of proteins. It's
a vital protein that helps in the production of high-density lipoprotein (HDL) particles, which …

Chemical cross‐linking and mass spectrometry to map three‐dimensional protein structures and protein–protein interactions

A Sinz - Mass spectrometry reviews, 2006 - Wiley Online Library
Closely related to studying the function of a protein is the analysis of its three‐dimensional
structure and the identification of interaction sites with its binding partners. An alternative …

High density lipoprotein structure–function and role in reverse cholesterol transport

S Lund-Katz, MC Phillips - … Transport Proteins: Structure and Function in …, 2010 - Springer
High density lipoprotein (HDL) possesses important anti-atherogenic properties and this
review addresses the molecular mechanisms underlying these functions. The structures and …

New insights into the determination of HDL structure by apolipoproteins1: Thematic Review Series: High Density Lipoprotein Structure, Function, and Metabolism

MC Phillips - Journal of lipid research, 2013 - ASBMB
Apolipoprotein (apo) AI is the principal protein component of HDL, and because of its
conformational adaptability, it can stabilize all HDL subclasses. The amphipathic α-helix is …

Myeloperoxidase: an oxidative pathway for generating dysfunctional high-density lipoprotein

B Shao, MN Oda, JF Oram… - Chemical research in …, 2010 - ACS Publications
Accumulation of low-density lipoprotein (LDL)-derived cholesterol by artery wall
macrophages triggers atherosclerosis, the leading cause of cardiovascular disease …

The structure of apolipoprotein AI in high density lipoproteins

WS Davidson, TB Thompson - Journal of Biological Chemistry, 2007 - ASBMB
Not long ago, high density lipoproteins (HDL) 2 were second class citizens with regard to
therapeutic strategies for lowering the risk of atherosclerosis and coronary artery disease …

RETRACTED: Crystal structure of human apolipoprotein AI: Insights into its protective effect against cardiovascular diseases

AA Ajees, GM Anantharamaiah, VK Mishra… - Proceedings of the …, 2006 - pnas.org
Despite three decades of extensive studies on human apolipoprotein AI (apoA-I), the major
protein component in high-density lipoproteins, the molecular basis for its antiatherogenic …

[HTML][HTML] Characterization of protein adsorption onto FePt nanoparticles using dual-focus fluorescence correlation spectroscopy

P Maffre, K Nienhaus, F Amin, WJ Parak… - Beilstein journal of …, 2011 - beilstein-journals.org
Using dual-focus fluorescence correlation spectroscopy, we have analyzed the adsorption of
three human blood serum proteins, namely serum albumin, apolipoprotein AI and …

Helical structure and stability in human apolipoprotein AI by hydrogen exchange and mass spectrometry

PS Chetty, L Mayne, S Lund-Katz… - Proceedings of the …, 2009 - National Acad Sciences
Apolipoprotein AI (apoA-I) stabilizes anti-atherogenic high density lipoprotein particles
(HDL) in the circulation and governs their biogenesis, metabolism, and functional …