The vast complexity of primary open angle glaucoma: disease genes, risks, molecular mechanisms and pathobiology

SF Janssen, TGMF Gorgels, WD Ramdas… - Progress in retinal and …, 2013 - Elsevier
Primary open angle glaucoma (POAG) is a complex progressive optic nerve neuropathy
triggered by both environmental and genetic risk factors. Several ocular tissues, including …

Maturation of the olfactory sensory neuron and its cilia

TS McClintock, N Khan, C Xie, JR Martens - Chemical Senses, 2020 - academic.oup.com
Olfactory sensory neurons (OSNs) are bipolar neurons, unusual because they turn over
continuously and have a multiciliated dendrite. The extensive changes in gene expression …

[HTML][HTML] The sense of smell impacts metabolic health and obesity

CE Riera, E Tsaousidou, J Halloran, P Follett, O Hahn… - Cell metabolism, 2017 - cell.com
Olfactory inputs help coordinate food appreciation and selection, but their role in systemic
physiology and energy balance is poorly understood. Here we demonstrate that mice upon …

Prolonged epigenomic and synaptic plasticity alterations following single exposure to a psychedelic in mice

M de la Fuente Revenga, B Zhu, CA Guevara, LB Naler… - Cell reports, 2021 - cell.com
Clinical evidence suggests that rapid and sustained antidepressant action can be attained
with a single exposure to psychedelics. However, the biological substrates and key …

Olfactory sensory neurons transiently express multiple olfactory receptors during development

L Tan, Q Li, XS Xie - Molecular systems biology, 2015 - embopress.org
In mammals, each olfactory sensory neuron randomly expresses one, and only one,
olfactory receptor (OR)—a phenomenon called the “one‐neuron‐one‐receptor” rule …

Axon-seq decodes the motor axon transcriptome and its modulation in response to ALS

J Nijssen, J Aguila, R Hoogstraaten, N Kee, E Hedlund - Stem cell reports, 2018 - cell.com
Spinal motor axons traverse large distances to innervate target muscles, thus requiring local
control of cellular events for proper functioning. To interrogate axon-specific processes we …

Methylomic changes during conversion to psychosis

O Kebir, B Chaumette, F Rivollier, F Miozzo… - Molecular …, 2017 - nature.com
The onset of psychosis is the consequence of complex interactions between genetic
vulnerability to psychosis and response to environmental and/or maturational changes …

Molecular and neuronal homology between the olfactory systems of zebrafish and mouse

LR Saraiva, G Ahuja, I Ivandic, AS Syed, JC Marioni… - Scientific reports, 2015 - nature.com
Studies of the two major olfactory organs of rodents, the olfactory mucosa (OM) and the
vomeronasal organ (VNO), unraveled the molecular basis of smell in vertebrates. However …

Amplification of olfactory signals by Anoctamin 9 is important for mammalian olfaction

H Kim, H Kim, LT Nguyen, T Ha, S Lim, K Kim… - Progress in …, 2022 - Elsevier
Sensing smells of foods, prey, or predators determines animal survival. Olfactory sensory
neurons in the olfactory epithelium (OE) detect odorants, where cAMP and Ca 2+ play a …

[HTML][HTML] Olfactory stimulation regulates the birth of neurons that express specific odorant receptors

CJ van der Linden, P Gupta, AI Bhuiya, KR Riddick… - Cell reports, 2020 - cell.com
In mammals, olfactory sensory neurons (OSNs) are born throughout life, ostensibly solely to
replace damaged OSNs. During differentiation, each OSN precursor" chooses," out of …