The treatment of multiple sclerosis has been transformed by the successful development of
immunotherapies that efficiently reduce disease activity and related clinical relapses during …

Oligodendrocytes generate multiple layers of myelin membrane around axons of the central
nervous system to enable fast and efficient nerve conduction. Until recently, saltatory nerve …

Oligodendrocyte dysfunction has been implicated in the pathogenesis of neurodegenerative
diseases, so understanding oligodendrocyte activation states would shed light on disease …

Since the molecular cloning of interleukin-6 (IL-6) in 1986, many other cytokines have been
found to share the same signal transducer, gp130, in their receptor complexes. Thus, the IL …

Astrocytes play important roles in numerous central nervous system disorders including
autoimmune inflammatory, hypoxic, and degenerative diseases such as Multiple Sclerosis …

Oligodendrocytes are the myelinating glia of the central nervous system. Myelination of
axons allows rapid saltatory conduction of nerve impulses and contributes to axonal …

Myelination is an essential process that consists of the ensheathment of axons by myelin. In
the central nervous system (CNS), myelin is synthesized by oligodendrocytes. The …

Although astrogliosis and microglia activation are characteristic features of multiple sclerosis
(MS) and other central nervous system (CNS) lesions the exact functions of these events are …

Myelin, the insulating layers of membrane wrapped around axons by oligodendrocytes, is
essential for normal impulse conduction. It forms during late stages of fetal development but …

Oligodendrocyte development is regulated by the interaction of repressors and activators in
a complex transcriptional network. We found that two histone-modifying enzymes, HDAC1 …