The term 'neurogenic inflammation'has been adopted to describe the local release of
inflammatory mediators, such as substance P and calcitonin gene‐related peptide, from …

Mast cells (MCs) are both sensors and effectors in communication among nervous, vascular,
and immune systems. In the brain, they reside on the brain side of the blood–brain barrier …

Mast cells can be found in close proximity to peripheral nerve endings where, upon
activation, they release a broad range of pro-inflammatory cytokines and chemokines …

Chronic pain is a major debilitating condition that is difficult to treat. Although chronic pain
may appear to be a disorder of the nervous system, crucial roles for immune cells and their …

Pain can be induced by tissue injuries, diseases and infections. The interactions between
the peripheral nervous system (PNS) and immune system are primary actions in pain …

Many sex differences in brain and behavior are programmed during development by
gonadal hormones, but the cellular mechanisms are incompletely understood. We found that …

Aim: Severe painful sensory neuropathy often occurs during paclitaxel chemotherapy. Since
paclitaxel can activate mast cell and basophils, whereas quercetin, a polyphenolic flavonoid …

Background Mast cell (MC) progenitors leave the bone marrow, enter the circulation, and
settle in the skin and other tissues. Their maturation in tissues is influenced by the …

Tick saliva has been extensively studied in the context of tick-host interactions because it is
involved in host homeostasis modulation and microbial pathogen transmission to the host …

Measuring inflammation-induced changes in thresholds of hind paw withdrawal from
mechanical pressure is a useful technique to assess changes in pain perception in rodents …