Intracochlear fibrosis and the foreign body response to cochlear implant biomaterials

MJ Foggia, RV Quevedo… - Laryngoscope …, 2019 - Wiley Online Library
Objective To report current knowledge on the topic of intracochlear fibrosis and the foreign
body response following cochlear implantation (CI). Methods A literature search was …

Advances in hearing preservation in cochlear implant surgery

O Tarabichi, M Jensen, MR Hansen - Current opinion in …, 2021 - journals.lww.com
Hearing preservation is possible using soft surgical techniques and electrode arrays
designed to minimize cochlear trauma; however, a subset of patients suffer from partial to …

Antifouling photograftable zwitterionic coatings on PDMS substrates

BL Leigh, E Cheng, L Xu, A Derk, MR Hansen… - Langmuir, 2018 - ACS Publications
The foreign body response (FBR) to implantable materials can negatively impact
performance of medical devices such as the cochlear implant. Engineering surfaces that …

Predictive factors for short‐and long‐term hearing preservation in cochlear implantation with conventional‐length electrodes

GB Wanna, BP O'Connell, DO Francis… - The …, 2018 - Wiley Online Library
Objectives/Hypothesis The aims of this study were to investigate short‐and long‐term rates
of hearing preservation after cochlear implantation and identify factors that impact hearing …

Potential insertion complications with cochlear implant electrodes

A Ishiyama, F Risi, P Boyd - Cochlear Implants International, 2020 - Taylor & Francis
Objectives: The aim of this discussion paper and literature review was to estimate the
incidence of a variety of complications associated with the surgical placement of cochlear …

Systematic literature review of hearing preservation rates in cochlear implantation associated with medium-and longer-length flexible lateral wall electrode arrays

PH Van de Heyning, S Dazert, J Gavilan… - Frontiers in …, 2022 - frontiersin.org
Background The last two decades have demonstrated that preoperative functional acoustic
hearing (residual hearing) can be preserved during cochlear implant (CI) surgery. However …

Cochlear implants: causes, effects and mitigation strategies for the foreign body response and inflammation

MT Rahman, DA Chari, G Ishiyama, I Lopez… - Hearing research, 2022 - Elsevier
Cochlear implants provide effective auditory rehabilitation for patients with severe to
profound sensorineural hearing loss. Recent advances in cochlear implant technology and …

Human histology after structure preservation cochlear implantation via round window insertion

A Geerardyn, MY Zhu, T Klabbers, W Huinck… - The …, 2024 - Wiley Online Library
Objectives Current surgical techniques aim to preserve intracochlear structures during
cochlear implant (CI) insertion to maintain residual cochlear function. The optimal technique …

Cochlear implantation with a dexamethasone eluting electrode array: functional and anatomical changes in non-human primates

R Manrique-Huarte, C Zulueta-Santos… - Otology & …, 2020 - journals.lww.com
Objectives: The aim of this study was to determine whether the dexamethasone-eluting
electrode (DEXEL) has a protective anti-inflammatory effect in a normal hearing implanted …

[HTML][HTML] Inner ear drug delivery through a cochlear implant: Pharmacokinetics in a Macaque experimental model

R Manrique-Huarte, MA de Linera-Alperi, D Parilli… - Hearing research, 2021 - Elsevier
Objectives The method of drug delivery directly into the cochlea with an implantable pump
connected to a CI electrode array ensures long-term delivery and effective dose control, and …