The current understanding of neurological diseases is derived mostly from direct analysis of
patients and from animal models of disease. However, most patient studies do not capture …

Developmental abnormalities of the cerebellum are among the most recognized structural
brain malformations in human prenatal imaging. Yet reliable information regarding their …

Medulloblastoma, a malignant childhood cerebellar tumour, segregates molecularly into
biologically distinct subgroups, suggesting that a personalized approach to therapy would …

The establishment and maintenance of apical‐basal polarity is a fundamental step in brain
development, instructing the organization of neural progenitor cells (NPCs) and the …

Research on human cerebellar development and disease has been hampered by the need
for a human cell-based system that recapitulates the human cerebellum's cellular diversity …

Neurons within the cerebellum form temporal–spatial connections through the cerebellum,
and the entire brain. Organoid models provide an opportunity to model the early …

ABSTRACT Patched 1 (PTCH1) is the primary receptor for the sonic hedgehog (SHH) ligand
and negatively regulates SHH signalling, an essential pathway in human embryogenesis …

Autism spectrum disorders (ASDs) are complex neurodevelopmental conditions
characterized by deficits in social interaction and communication, as well as repetitive …

Modeling the heterogeneity of the tumor microenvironment (TME) in vitro is essential to
investigating fundamental cancer biology and developing novel treatment strategies that …

Alzheimer's disease (AD) is a progressive, neurodegenerative disease that has emerged as
a leading risk factor for dementia associated with increasing age. Two‐dimensional (2D) cell …