Cancer is a leading public health problem worldwide. Its treatment remains a daunting
challenge, although significant progress has been made in existing treatments in recent …

In the past decade, there has been a shift in research, clinical development, and commercial
activity to exploit the many physiological roles of RNA for use in medicine. With the rapid …

Research over the past decade has extended the prevailing view of the mitochondrion to
include functions well beyond the generation of cellular energy. It is now recognized that …

The increasing morbidity of oral diseases, such as dental caries, periodontitis and oral
cancer, has greatly compromised the life quality of humans. With the rapid development of …

Advanced drug delivery systems (DDS) present indubitable benefits for drug administration.
Over the past three decades, new approaches have been suggested for the development of …

Neurodegenerative diseases (NDDs) originate from a loss of neurons in the central nervous
system and are severely debilitating. The incidence of NDDs increases with age, and they …

With the first RNA interference (RNAi) drug (ONPATTRO (patisiran)) on the market, we
witness the RNAi therapy field reaching a critical turning point, when further improvements in …

RNA interference currently offers new opportunities for gene therapy by the specific
extinction of targeted gene (s) in cancer diseases. However, the main challenge for nucleic …

MicroRNAs are a highly conserved group of small, non-coding RNA molecules, which are
19-25 nucleotides in size. Previously thought to be evolutionary debris with no evident …

In the past few decades, substantial advancement has been made in nucleic acid (NA)-
based therapies. Promising treatments include mRNA, siRNA, miRNA, and anti-sense DNA …