The beneficial pharmacological effects of Uncaria rhynchophylla in neurodegenerative diseases: focus on alkaloids

L Chen, Y Liu, J Xie - Frontiers in Pharmacology, 2024 - frontiersin.org
With the intensification of aging population, the prevention or treatment of
neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease, has …

[HTML][HTML] Genipin and pyrogallol: Two natural small molecules targeting the modulation of disordered proteins in Alzheimer's disease

S Kim, Y Nam, SJ Shin, D Im, H soo Kim… - Biomedicine & …, 2023 - Elsevier
Alzheimer's disease (AD) is characterized by the aggregation of disordered proteins, such
as amyloid beta (Aβ) and tau, leading to neurotoxicity and disease progression. Despite …

Development of a novel UHPLC-MS/MS method for the quantification of corynoxeine: Application to pharmacokinetics and tissue distribution studies in normal and …

Q Sun, N Zhao, T Zhang, S Wang, L Wang… - Journal of Pharmaceutical …, 2024 - Elsevier
Corynoxeine, a natural active alkaloid found in Genus Uncaria, has been reported to have
anti-depressant effects. In this study, a sensitive and efficient ultra-high performance liquid …

Korean red ginseng polysaccharide as a potential therapeutic agent targeting tau pathology in Alzheimer's disease

S Kim, SJ Shin, Y Nam, YH Park, BH Kim… - International Journal of …, 2024 - Elsevier
Tau is a microtubule-associated protein that plays a critical role in the stabilization and
modulation of neuronal axons. Tau pathology is stronger associated with cognitive decline …

Anti‐Glycation, Anti‐β‐Amyloid Aggregation, and Antioxidant Effect of Cassia Seed‐Derived Secondary Metabolites

P Paudel, R Prajapati, HJ Lim… - Journal of Food …, 2023 - Wiley Online Library
Aggregation and non‐enzymatic glycation of amyloidogenic peptides, amyloid‐beta (Aβ),
and insulin are key features of neuropathology. In this study, we evaluate the anti‐glycation …

[HTML][HTML] Investigation of Novel Aronia Bioactive Fraction-Alginic Acid Nanocomplex on the Enhanced Modulation of Neuroinflammation and Inhibition of Aβ …

BK Jang, SJ Shin, HH Park, V Kumar, YH Park, JY Kim… - Pharmaceutics, 2024 - mdpi.com
Background/Objectives: Aronia extract or its active compounds, especially anthocyanin,
have shown potential for Alzheimer's disease (AD)-related pathologies, including …

[HTML][HTML] Screening of a Fraction with Higher Amyloid β Aggregation Inhibitory Activity from a Library Containing 210 Mushroom Extracts Using a Microliter-Scale High …

G Huanood, MMM Swamy, R Sasaki, K Shimamori… - Foods, 2024 - mdpi.com
Alzheimer's disease (AD) is a highly prevalent neurodegenerative disease hallmarked by
amyloid plaques and neurofibrillary tangles. Amyloid plaques are formed by the amyloid β …

Simultaneous stereoisomeric preconcentration and determination of alkaloids and stereoisomers in Uncariae ramulus cum uncis using field enhanced sample …

W Liu, Y Yao, J Wen, L Huang, S Chen… - … of Chromatography A, 2025 - Elsevier
A rapid and sensitive enrichment technique, field enhanced sample injection-dynamic pH
junction-sweeping (FESI-DypH-sweeping) was successfully developed for the simultaneous …

Salvianolic acid B exerts protective effects against Aβ-induced neuroinflammation through the inhibition of NLRP3 inflammasome activation and switching of M1/M2 …

Y Zhao, X Liu, X Liu, J Zhang, Y Zhang, Y Wen, G Yang - Tissue and Cell, 2023 - Elsevier
Abstract Background Salvianolic acid B (SalB) is a bioactive extract of Salvia miltiorrhiza
with the ability to ameliorate amyloid beta (Aβ)-induced neuronal degeneration and …

[PDF][PDF] Research Article Anti-Glycation, Anti-β-Amyloid Aggregation, and Antioxidant Effect of Cassia Seed-Derived Secondary Metabolites

P Paudel, R Prajapati, HJ Lim, S Shrestha, SH Seong… - 2023 - academia.edu
Aggregation and non• enzymatic glycation of amyloidogenic peptides, amyloid• beta (Aβ),
and insulin are key features of neuropathology. In this study, we evaluate the anti• glycation …