The placenta is the main determinant of fetal growth and development in utero. It supplies all
the nutrients and oxygen required for fetal growth and secretes hormones that facilitate …

Insulin-like growth factor 2 (IGF2) is upregulated in both childhood and adult malignancies.
Its overexpression is associated with resistance to chemotherapy and worse prognosis …

Targeted degradation of the cell-surface and extracellular proteins via the endogenous
lysosomal degradation pathways, such as lysosome-targeting chimeras (LYTACs), has …

Upregulation of IGF2 occurs in both childhood and adult malignancies. Its overexpresssion
is associated with resistance to chemotherapy and worse prognosis. IGF2 promoter usage is …

Circular RNAs (circRNAs) drive several cellular processes including proliferation, survival,
and differentiation. Here, we identified a circRNA hsa_circ_0007813, whose expression was …

The growth hormone (GH)–insulin-like growth factor (IGF) axis is one of the main drivers of
mammalian growth and development. Pituitary secretion of GH is pulsatile and under …

In all eutherian mammals, growth of the fetus is dependent upon a functional placenta, but
whether and how the latter adapts to putative fetal signals is currently unknown. Here, we …

The insulin-like growth factor (IGF) system regulates metabolic and mitogenic signaling
through an intricate network of related receptors and hormones. IGF-II is one of several …

The insulin receptor (IR) presents by alternative splicing two isoforms: IRA and IRB. The
differential physiological and pathological role of both isoforms is not completely known, and …

Cervical cancer is the most common gynecological malignancy in the world; however, the
survival rates of advanced-stage and recurrent cervical cancer patients remain poor. The …