Simple Summary Vincristine is a vinca alkaloid naturally occurring in Catharanthus roseus. It
belongs to antimitotic compounds, which arrest the cell cycle via disrupting microtubule …

Despite the huge investment into research and the significant effort and advances made in
the search for new anticancer drugs in recent decades, cancer cure and treatment continue …

The demand for natural product is growing their interest in our daily life. It makes
Catharanthus roseus (L.) G. Don a crucial member of family Apocynaceae due to having its …

Microtubules (MTs) are highly conserved polar polymers that are key elements of the
eukaryotic cytoskeleton and are essential for various cell functions. αβ-tubulin, a …

The chemical investigation of marine mollusks has led to the isolation of a wide variety of
bioactive metabolites, which evolved in marine organisms as favorable adaptations to …

The voltage-dependent anion channel (VDAC) is the primary regulating pathway of water-
soluble metabolites and ions across the mitochondrial outer membrane. When reconstituted …

Microtubule-targeting agents (MTAs) like taxol and vinblastine are among the most
successful chemotherapeutic drugs against cancer. Here, we describe a fluorescence …

A biotransformation pair consisting of vinblastine: vincristine present in the Catharanthus
roseus plant is of immense pharmacological significance. In this study, we successfully …

Covering: 1957 to 2017 Algae constitute a heterogeneous group of eukaryotic
photosynthetic organisms, mainly found in the marine environment. Algae produce …

Dimeric tubulin, an abundant water-soluble cytosolic protein known primarily for its role in
the cytoskeleton, is routinely found to be associated with mitochondrial outer membranes …