Allergen exposure chambers: harmonizing current concepts and projecting the needs for the future–an EAACI Position Paper

O Pfaar, MA Calderon, CP Andrews, E Angjeli… - Allergy, 2017 - Wiley Online Library
Background Allergen exposure chambers (AEC s) are clinical facilities allowing for
controlled exposure of subjects to allergens in an enclosed environment. AEC s have …

Aeroallergens in Canada: distribution, public health impacts, and opportunities for prevention

C Sierra-Heredia, M North, J Brook, C Daly… - International journal of …, 2018 - mdpi.com
Aeroallergens occur naturally in the environment and are widely dispersed across Canada,
yet their public health implications are not well-understood. This review intends to provide a …

[HTML][HTML] Birch-induced allergic rhinitis: Results of exposure during nasal allergen challenge, environmental chamber, and pollen season

A Gherasim, F Dietsch, M Beck, N Domis… - World Allergy …, 2023 - Elsevier
Background Pollen variation can affect field study data quality. Nasal allergen challenge
(NAC) is considered the gold standard for evaluating allergic rhinitis, while environmental …

Treatment with grass allergen peptides improves symptoms of grass pollen–induced allergic rhinoconjunctivitis

AK Ellis, CW Frankish, RE O'Hehir, K Armstrong… - Journal of Allergy and …, 2017 - Elsevier
Background Synthetic peptide immunoregulatory epitopes are a new class of
immunotherapy to treat allergic rhinoconjunctivitis (ARC). Grass allergen peptides …

Blood and nasal epigenetics correlate with allergic rhinitis symptom development in the environmental exposure unit

ML North, MJ Jones, JL MacIsaac, AM Morin… - Allergy, 2018 - Wiley Online Library
Background Epigenetic alterations may represent new therapeutic targets and/or biomarkers
of allergic rhinitis (AR). Our aim was to examine genome‐wide epigenetic changes induced …

Allergen exposure chambers: implementation in clinical trials in allergen immunotherapy

O Pfaar, P Zieglmayer - Clinical and Translational Allergy, 2020 - Springer
Allergen exposure chambers (AECs) have been developed for controlled allergen
challenges of allergic patients mimicking natural exposure. As such, these facilities have …

[HTML][HTML] Specificity and reproducibility of nasal biomarkers in patients with allergic rhinitis after allergen challenge chamber exposure

P Badorrek, M Müller, W Koch, JM Hohlfeld… - Annals of Allergy, Asthma …, 2017 - Elsevier
Background Allergic rhinitis is an inflammatory disease that causes cellular influx and
mediator release in the nose. These inflammatory changes might be used as nasal …

Decongestant Effect of “Coldamaris Akut”, a Carrageenan-and Sorbitol-Containing Nasal Spray in Seasonal Allergic Rhinitis

N Unger-Manhart, M Morokutti-Kurz… - … Journal of General …, 2024 - Taylor & Francis
Purpose This study aimed to develop a hyperosmolar, barrier-forming nasal spray based on
carrageenan and sorbitol, and to demonstrate its decongestant effect in the context of …

Lack of effect of Timothy grass pollen sublingual immunotherapy tablet on birch pollen–induced allergic rhinoconjunctivitis in an environmental exposure unit

AK Ellis, MW Tenn, LM Steacy, DE Adams… - Annals of Allergy …, 2018 - Elsevier
Background Timothy grass pollen allergen extract tablets (Grastek) are standardized
sublingual immunotherapy tablets (SLIT-T) approved for the treatment of grass pollen …

Advances in rhinitis: Models and mechanisms

AK Ellis, MW Tenn - Annals of Allergy, Asthma & Immunology, 2018 - Elsevier
Objective To summarize studies highlighting recent advances in rhinitis-related research in
the past 2 years. Data Sources Original research articles were procured and examined from …