Nebulised unfractionated heparin (UFH) has a strong scientific and biological rationale and
warrants urgent investigation of its therapeutic potential, for COVID-19-induced acute …

Heparin is the earliest and most widely used anticoagulant and antithrombotic drug that is
still used in a variety of clinical indications. Since it was discovered in 1916, after more than …

Background Mechanical ventilation in intensive care for 48 h or longer is associated with the
acute respiratory distress syndrome (ARDS), which might be present at the time ventilatory …

Objective: To test the hypothesis that the concentration of angiopoietin-2 relative to
angiopoietin-1 may be a useful biological marker of mortality in acute lung injury patients …

Introduction Prolonged mechanical ventilation has the potential to aggravate or initiate
pulmonary inflammation and cause lung damage through fibrin deposition. Heparin may …

Aims To determine the safety and efficacy‐potential of inhaled nebulised unfractionated
heparin (UFH) in the treatment of hospitalised patients with COVID‐19. Methods …

Aims Inhaled nebulised unfractionated heparin (UFH) has a strong scientific and biological
rationale that warrants urgent investigation of its therapeutic potential in patients with COVID …

Introduction Animal studies of acute lung injury (ALI) suggest nebulised heparin may limit
damage from fibrin deposition in the alveolar space and microcirculation. No human studies …

Purpose Nebulized heparin may reduce fibrin cast formation and reduce the degree of
airway obstruction in burn inhalation injury. Methods Twenty-nine patients admitted to burn …

Abstract Purpose To determine whether VDPhys/VT is associated with coagulation
activation and outcomes. Materials and methods We enrolled patients with COVID-19 …