Hyperglycemia associated with diabetes mellitus results in the priming of neutrophils
leading to oxidative stress that is, in part, responsible for diabetic complications. p47 phox, a …

Diacylglycerol is a key regulator of cell physiology, controlling the membrane recruitment
and activation of signaling molecules. Accordingly, diacylglycerol generation and …

The mechanism promoting exacerbated immune responses in allergy and autoimmunity as
well as those blunting the immune control of cancer cells are of primary interest in medicine …

Ten mammalian diacylglycerol kinase (DGK) isozymes (a-γ) have been identified. Recent
studies have revealed that DGK isozymes play pivotal roles in a wide variety of …

While it has been reported that genistein induces differentiation in multiple tumour cell
models, the signalling and regulation of isoflavone-provoked differentiation are poorly …

AIM: To investigate whether the apoptotic activities of 8-bromo-7-methoxychrysin (BrMC)
involve reactive oxygen species (ROS) generation and c-Jun N-terminal kinase (JNK) …

We recently reported that heparanase, one of the extracellular matrix‐degrading enzymes,
which plays a critical role in cancer progression, is located not only in the cytoplasm but also …

To evaluate the role of redox homeostasis in differentiation in human promyelocytic
leukemia cells (HL‐60) induced by isoliquiritigenin (ISL) through modulation of the nuclear …

Ultra-weak photon emission (UPE) is light emitted spontaneously by biological systems
without the use of specific luminescent complexes. UPE is emitted in the near-UV/UV …

Among various cancer cell lines, the leukemia cell line HL‐60 was most sensitive to
Shikonin, with evidence showing both the prooxidative activities and proapoptotic effects of …