Matrix metalloproteinase-8 inhibition prevents disruption of blood–spinal cord barrier and attenuates inflammation in rat model of spinal cord injury
After spinal cord injury (SCI), tight junction (TJ) protein degradation increases permeability
and disrupts the blood–spinal cord barrier (BSCB). The BSCB is primarily formed of …
and disrupts the blood–spinal cord barrier (BSCB). The BSCB is primarily formed of …
Ursodeoxycholic acid inhibits inflammatory responses and promotes functional recovery after spinal cord injury in rats
The aim of this study was to investigate the anti-inflammatory effects by ursodeoxycholic acid
(UDCA) in rats with a spinal cord injury (SCI). A moderate mechanical compression injury …
(UDCA) in rats with a spinal cord injury (SCI). A moderate mechanical compression injury …
TGN-020 alleviates edema and inhibits astrocyte activation and glial scar formation after spinal cord compression injury in rats
J Li, Z Jia, W Xu, W Guo, M Zhang, J Bi, Y Cao, Z Fan… - Life sciences, 2019 - Elsevier
Aims Identifying drugs that inhibit edema and glial scar formation and increase neuronal
survival is crucial to improving outcomes after spinal cord injury (SCI). Here, we used 2 …
survival is crucial to improving outcomes after spinal cord injury (SCI). Here, we used 2 …
A biocompatible gelatin sponge scaffold confers robust tissue remodeling after spinal cord injury in a non-human primate model
X Zeng, Q Wei, J Ye, J Rao, M Zheng, Y Ma, L Peng… - Biomaterials, 2023 - Elsevier
We previously constructed a three-dimensional gelatin sponge (3D-GS) scaffold as a
delivery vehicle for therapeutic cells and trophic factors in the treatment of spinal cord injury …
delivery vehicle for therapeutic cells and trophic factors in the treatment of spinal cord injury …
Inhibition of ERK1/2 phosphorylation attenuates spinal cord injury induced astrocyte activation and inflammation through negatively regulating aquaporin-4 in rats
J Li, Z Jia, Q Zhang, J Dai, J Kong, Z Fan, G Li - Brain Research Bulletin, 2021 - Elsevier
The extracellular signal-regulated kinase (ERK) pathway has been reported to play a pivotal
role in mediating spinal cord injury (SCI) progression. The present study aimed to …
role in mediating spinal cord injury (SCI) progression. The present study aimed to …
Molecular design strategies of multifunctional probe for simultaneous monitoring of Cu2+, Al3+, Ca2+ and endogenous L-phenylalanine (LPA) recognition in living …
G Zhao, C Yi, G Wei, R Wu, Z Gu, S Guang… - Journal of hazardous …, 2020 - Elsevier
An innovative strategy of adjusting the molecular polarity of organics is applied for
multifunctional simultaneous ions detection. It involved the use of 4-bromo-2-hydroxyben …
multifunctional simultaneous ions detection. It involved the use of 4-bromo-2-hydroxyben …
Perineurium-like sheath derived from long-term surviving mesenchymal stem cells confers nerve protection to the injured spinal cord
YH Ma, X Zeng, XC Qiu, QS Wei, MT Che, Y Ding, Z Liu… - Biomaterials, 2018 - Elsevier
The functional multipotency enables mesenchymal stem cells (MSCs) promising
translational potentials in treating spinal cord injury (SCI). Yet the fate of MSCs grafted into …
translational potentials in treating spinal cord injury (SCI). Yet the fate of MSCs grafted into …
Coexistence of chronic hyperalgesia and multilevel neuroinflammatory responses after experimental SCI: a systematic approach to profiling neuropathic pain
L Wang, MA Gunduz, AT Semeano, EC Yılmaz… - Journal of …, 2022 - Springer
Background People with spinal cord injury (SCI) frequently develop neuropathic pain (NP)
that worsens disability and diminishes rehabilitation efficacy. Chronic NP is presently …
that worsens disability and diminishes rehabilitation efficacy. Chronic NP is presently …
Neutrophil elastase inhibition effectively rescued angiopoietin-1 decrease and inhibits glial scar after spinal cord injury
After spinal cord injury (SCI), neutrophil elastase (NE) released at injury site disrupts
vascular endothelium integrity and stabilization. Angiopoietins (ANGPTs) are vascular …
vascular endothelium integrity and stabilization. Angiopoietins (ANGPTs) are vascular …
Elevated TRPV4 levels contribute to endothelial damage and scarring in experimental spinal cord injury
Currently, the role of transient receptor potential vanilloid type 4 (TRPV4), a nonselective
cation channel in the pathology of spinal cord injury (SCI), is not recognized. Herein, we …
cation channel in the pathology of spinal cord injury (SCI), is not recognized. Herein, we …