Endless forms most beautiful 2.0: teleonomy and the bioengineering of chimaeric and synthetic organisms

WP Clawson, M Levin - Biological Journal of the Linnean …, 2023 - academic.oup.com
The rich variety of biological forms and behaviours results from one evolutionary history on
Earth, via frozen accidents and selection in specific environments. This ubiquitous baggage …

Enhancing nervous system recovery through neurobiologics, neural interface training, and neurorehabilitation

MO Krucoff, S Rahimpour, MW Slutzky… - Frontiers in …, 2016 - frontiersin.org
After an initial period of recovery, human neurological injury has long been thought to be
static. In order to improve quality of life for those suffering from stroke, spinal cord injury, or …

Trunk stability enabled by noninvasive spinal electrical stimulation after spinal cord injury

M Rath, AH Vette, S Ramasubramaniam, K Li… - Journal of …, 2018 - liebertpub.com
Electrical neuromodulation of spinal networks improves the control of movement of the
paralyzed limbs after spinal cord injury (SCI). However, the potential of noninvasive spinal …

Transcutaneous spinal cord stimulation and motor responses in individuals with spinal cord injury: A methodological review

C Taylor, C McHugh, D Mockler, C Minogue… - PLoS …, 2021 - journals.plos.org
Background Transcutaneous spinal cord stimulation (tSCS) is a non-invasive modality in
which electrodes can stimulate spinal circuitries and facilitate a motor response. This review …

Immediate effects of transcutaneous spinal cord stimulation on motor function in chronic, sensorimotor incomplete spinal cord injury

C Meyer, US Hofstoetter, M Hubli, RH Hassani… - Journal of clinical …, 2020 - mdpi.com
Deficient ankle control after incomplete spinal cord injury (iSCI) often accentuates walking
impairments. Transcutaneous electrical spinal cord stimulation (tSCS) has been shown to …

Spinal cord stimulation and augmentative control strategies for leg movement after spinal paralysis in humans

K Minassian, US Hofstoetter - CNS neuroscience & …, 2016 - Wiley Online Library
Severe spinal cord injury is a devastating condition, tearing apart long white matter tracts
and causing paralysis and disability of body functions below the lesion. But caudal to most …

Maturation of the locomotor circuitry in children with cerebral palsy

G Cappellini, F Sylos-Labini, AH Dewolf… - … in Bioengineering and …, 2020 - frontiersin.org
The first years of life represent an important phase of maturation of the central nervous
system, processing of sensory information, posture control and acquisition of the locomotor …

Biology, Buddhism, and AI: Care as the driver of intelligence

T Doctor, O Witkowski, E Solomonova, B Duane… - Entropy, 2022 - mdpi.com
Intelligence is a central feature of human beings' primary and interpersonal experience.
Understanding how intelligence originated and scaled during evolution is a key challenge …

Epidural stimulation combined with triple gene therapy for spinal cord injury treatment

R Islamov, F Bashirov, F Fadeev… - International Journal of …, 2020 - mdpi.com
The translation of new therapies for spinal cord injury to clinical trials can be facilitated with
large animal models close in morpho-physiological scale to humans. Here, we report …

Inosine–A multifunctional treatment for complications of neurologic injury

C Doyle, V Cristofaro, MP Sullivan… - Cellular Physiology and …, 2018 - karger.com
Spinal cord injury (SCI) caused by trauma or disease leads to motor and sensory
abnormalities that depend on the level, severity and duration of the lesion. The most obvious …