Pancreatic stellate cells (PaSCs) are myofibroblast-like cells found in the areas of the
pancreas that have exocrine function. PaSCs are regulated by autocrine and paracrine …

Activated pancreatic stellate cells (PSCs) are the main effector cells in the process of
fibrosis, a major pathological feature in pancreatic diseases that including chronic …

The field of pancreatic stellate cell (PSC) biology is very young, as the essential invitro tools
to study these cells (ie, methods to isolate and culture PSC) were only developed as recently …

Pancreatic stellate cells, normally quiescent, are capable of remarkable transition into their
activated myofibroblast-like phenotype. It is now commonly accepted that these cells play a …

Pancreatic fibrosis is a characteristic feature of chronic pancreatitis and of desmoplastic
reaction associated with pancreatic cancer. For over a decade, there has been accumulating …

Liver fibrosis results from dysregulation of normal wound healing, inflammation, activation of
myofibroblasts, and deposition of extracellular matrix (ECM). Chronic liver injury causes …

Aims Multidrug resistance in pancreatic cancer poses a significant challenge in clinical
treatment. Bufalin (BA), a compound found in secretions from the glands of toads, may help …

Background Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant disease with a
very poor prognosis. To date patient outcomes have not improved principally due to the …

Pancreatic stellate cells (PSCs) play a crucial role in pancreatic fibrogenesis in chronic
pancreatitis and in the desmoplastic reaction of pancreatic cancer. When PSCs are …

Hepatic stellate cells (HSCs), also known as perisinusoidal cells, are pericytes found in the
perisinusoidal space of the liver. HSCs are the major cell type involved in liver fibrosis …