Biotransformation of arsenic and toxicological implication of arsenic metabolites

S Hirano - Archives of toxicology, 2020 - Springer
Arsenic is a well-known environmental carcinogen and chronic exposure to arsenic through
drinking water has been reported to cause skin, bladder and lung cancers, with arsenic …

Mechanisms associated with cognitive and behavioral impairment induced by arsenic exposure

GI Vázquez Cervantes, DF González Esquivel… - Cells, 2023 - mdpi.com
Arsenic (As) is a metalloid naturally present in the environment, in food, water, soil, and air;
however, its chronic exposure, even with low doses, represents a public health concern. For …

Arsenic Metabolism in Mice Carrying a BORCS7/AS3MT Locus Humanized by Syntenic Replacement

BH Koller, JN Snouwaert, C Douillet… - Environmental …, 2020 - ehp.niehs.nih.gov
Background: Chronic exposure to inorganic arsenic (iAs) is a significant public health
problem. Methylation of iAs by arsenic methyltransferase (AS3MT) controls iAs detoxification …

Fate of arsenicals in mice carrying the human AS3MT gene exposed to environmentally relevant levels of arsenite in drinking water

C Douillet, M Miller, PH Cable, Q Shi, H El-Masri… - Scientific Reports, 2023 - nature.com
Although mice are widely used to study adverse effects of inorganic arsenic (iAs), higher
rates of iAs methylation in mice than in humans may limit their utility as a model organism. A …

Arsenic exposure decreases adiposity during high‐fat feeding

CM Carmean, AG Kirkley, M Landeche, H Ye… - …, 2020 - Wiley Online Library
Objective Arsenic is an endocrine‐disrupting chemical associated with diabetes risk.
Increased adiposity is a significant risk factor for diabetes and its comorbidities. Here, the …

Chronic arsenic exposure affects stromal cells and signaling in the small intestine in a sex-specific manner

SW Ventrello, NR McMurry, NM Edwards… - Toxicological …, 2024 - academic.oup.com
Arsenic is a toxicant that is ingested through drinking water and food, exposing nearly 140
million people to levels above the 10 ppb guideline concentration. Studies have shown that …

Application of the in vivo oxidative stress reporter Hmox1 as mechanistic biomarker of arsenic toxicity

F Inesta-Vaquera, P Navasumrit, CJ Henderson… - Environmental …, 2021 - Elsevier
Inorganic arsenic (iAs) is a naturally occurring metalloid present in drinking water and
polluted air exposing millions of people globally. Epidemiological studies have linked iAs …

Distribution of arsenic species and pathological characteristics of tissues of the mice fed with arsenic-supplemented food simulating rice

J Shao, X Li, Y Luo, H Fang, F Lin, G Zhang… - The Journal of …, 2021 - jstage.jst.go.jp
The exposure and harm of arsenic have attracted wide attention. Rice is an arsenic-rich
crop. The purpose of this study was to learn the distribution of arsenic species and the …

Differential Selectivity of Human and Mouse ABCC4/Abcc4 for Arsenic Metabolites

BD Whitlock, Y Ma, G Conseil, AR O'Brien… - Drug Metabolism and …, 2024 - Elsevier
Millions of people globally are exposed to the proven human carcinogen arsenic at
unacceptable levels in drinking water. In contrast, arsenic is a poor rodent carcinogen …

Host genetics and gut microbiota cooperatively contribute to azoxymethane-induced acute toxicity in Collaborative Cross mice

C Zhong, L He, SY Lee, H Chang, Y Zhang… - Archives of …, 2021 - Springer
Azoxymethane (AOM) is a widely used carcinogen to study chemical-induced colorectal
carcinogenesis and is an agent for studying fulminant hepatic failure. The inter-strain …