Recent advances have revealed common pathological changes in neurodegenerative
diseases, such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral …

Cellular trafficking is essential to maintain critical biological functions. Mutations in 346
genes, most of them described in the last 5 years, are associated with disorders of cellular …

The proteins of the BCL-2 family are known as key regulators of apoptosis, with interactions
between family members determining permeabilisation of the mitochondrial outer …

Mitochondria are double membrane organelles within eukaryotic cells, which act as cellular
power houses, depending on the continuous availability of oxygen. Nevertheless, under …

The outer mitochondrial membrane is a busy place. One essential activity for cellular
survival is the regulation of membrane integrity by the BCL‐2 family of proteins. Another …

T cell activation process is critically affected by temperature and intracellular Ca 2+-
signalling. Yet, the nature and the key molecules involved in such complex Ca 2+-signalling …

Excessive mitochondrial fission in podocytes is a critical feature of diabetic nephropathy
(DN). Mitochondria-associated endoplasmic reticulum membranes (MAMs) are contact sites …

The complex physiology of eukaryotic cells requires that a variety of subcellular organelles
perform unique tasks, even though they form highly dynamic communication networks. In the …

VEGFR2 signaling in endothelial cells (ECs) is regulated by reactive oxygen species (ROS)
derived from NADPH oxidases (NOXs) and mitochondria, which plays an important role in …

Age-related macular degeneration (AMD) is a progressive neurodegenerative disease
affecting the central area (macula lutea) of the retina. Research on the pathogenic …