Collagen is one of the most useful biopolymers because of its low immunogenicity and
biocompatibility. The biomedical potential of natural collagen is limited by its poor …

Current in-vitro 2D cultures and animal models present severe limitations in recapitulating
human physiopathology with striking discrepancies in estimating drug efficacy and side …

Cell motility is essential for life and development. Unfortunately, cell migration is also linked
to several pathological processes, such as cancer metastasis. Cells' ability to migrate relies …

Bone is an active organ that continuously undergoes an orchestrated process of remodeling
throughout life. Bone tissue is uniquely capable of adapting to loading, hormonal, and other …

Understanding complex cell–cell interactions and physiological microenvironments is critical
for the development of new therapies for treating human diseases. Current animal models …

The heterogeneity of native tissues requires complex materials to provide suitable
substitutes for model systems and replacement tissues. Functionally graded materials have …

Microfluidics is a very useful and promising technology that allowed engineering a huge
variety of developments in several fields, such as biology, biomedical engineering …

In this work, we show how the mechanical properties of the cellular microenvironment
modulate the growth of tumour spheroids. Based on the composition of the extracellular …

Collagen hydrogels are widely used for in-vitro experiments and tissue engineering
applications. Their use has been extended due to their biocompatibility with cells and their …

Mechanical environment has a crucial role in our organism at the different levels, ranging
from cells to tissues and our own organs. This regulatory role is especially relevant for …