Since the advent of penicillin, the β-lactam antibiotics have been the subject of much
discussion and investigation within both the scientific and public sectors. β-Lactam …

During the last three decades the use of hydrolases for the catalysis of environmentally
friendly organic processes under mild reaction conditions has been well documented …

Many drugs currently used are covalent inhibitors and irreversibly inhibit their targets. Most
of these were discovered through serendipity. Covalent inhibitions can have many …

With recent outbreaks of COVID-19 and Ebola, health and healthcare have once more
shown to be heavily burdened by the lack of generally effective anti-viral therapies. Initial …

Chiral nitrogenated compounds are highly attractive compounds because of their
importance in agrochemicals, fine chemicals, and pharmaceuticals but also due to their …

Biocatalysis is a valuable industrial approach in active pharmaceutical ingredient (API)
manufacturing for asymmetric induction and synthesis of chiral APIs. Herein, we investigated …

The last frontier in the development of chiral stationary phases for chromatographic
enantioseparation involves homochiral metal–organic frameworks (MOFs). Using …

In contrast to alcohols and amines, racemic lactams and thiolactams cannot be resolved
directly via enzymatic acylation or classical resolution. Asymmetric N-acylation promoted by …

A new family of polystyrene‐supported cis‐4‐hydroxydiphenylprolinol silyl ethers has been
prepared, and the resulting polymers have been evaluated as organocatalysts to promote …

Rhodium-Catalyzed Asymmetric Addition of Arylboronic Acids to β-Phthaliminoacrylate Esters
toward the Synthesis of β-Amino Acids | Journal of the American Chemical Society ACS ACS …