The lungs are affected by illnesses including asthma, chronic obstructive pulmonary
disease, and infections such as influenza and SARS-CoV-2. Physiologically relevant models …

Endocytosis, or internalization through endosomes, is a major cell entry mechanism used by
respiratory viruses. Phosphoinositide 5-kinase (PIKfyve) is a critical enzyme for the synthesis …

The past five decades have witnessed remarkable advancements in the field of inhaled
medicines targeting the lungs for respiratory disease treatment. As a non-invasive drug …

Bats are reservoir hosts for various zoonotic viruses with pandemdic potential in humans
and livestock. In vitro systems for studying bat host–pathogen interactions are of significant …

The field of 3D bioprinting is rapidly evolving, and the lung is not being left behind.
Interdisciplinary advances in 3D printing technology, bioink formulations, and cell biology …

Human microphysiological systems, such as organs on chips, are an emerging technology
for modeling human physiology in a preclinical setting to understand the mechanism of …

Background Elderly people are known to be vulnerable to virus infection. However, this has
not been appropriately tested in in vitro studies due to a lack of appropriate virus infection …

Chronic use of β 2-adrenoceptor agonists as a monotherapy in asthma is associated with a
loss of disease control and an increased risk of mortality. Herein, we tested the hypothesis …

Roles for the baculoviral inhibitor of apoptosis repeat-containing (BIRC) genes, BIRC2 and
BIRC3, may include signaling to the inflammatory transcription factor, nuclear factor-κB (NF …

While glucocorticoids act via the glucocorticoid receptor (GR; NR3C1) to reduce the
expression of many inflammatory genes, repression is not an invariable outcome. Here, we …