Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the
accumulation of beta-amyloid (Aβ) protein and neurofibrillary tangles in the brain, resulting …

Alzheimer's disease (AD) is the most common form of dementia affecting specifically older
population. AD is an irreversible neurodegenerative CNS disorder associated with complex …

A systematic, rational search for chalcone derivatives with multifunctional behavior has been
carried out, with the support of a computer-assisted protocol (CADMA-Chem). A total of 568 …

The oral administration of donepezil hydrochloride has low brain targeting efficiency
especially due to the presence of the blood–brain barrier leading to poor quality of …

Due to the hugely important roles of neurotransmitter acetylcholine (ACh) and amyloid-β
(Aβ) in the pathogenesis of Alzheimer's disease (AD), the development of multi-target …

Under the guidance of the approach which integrates molecular networking,
MolNetEnhancer and Network Annotation Propagation (NAP), daphnaltaicanoids A and B (1 …

Based on a multitarget strategy, a series of novel chromanone–1-benzyl-1, 2, 3, 6-
tetrahydropyridin hybrids were identified for the potential treatment of Alzheimer's disease …

Background There is no doubt that Alzheimer's disease (AD) is one of the greatest threats
facing mankind today. Within the next few decades, Acetylcholinesterase inhibitors (AChEIs) …

Six new isoquinoline alkaloids, including aporphine alkaloids (2, 3, 9, and 10), a
benzylisoquinoline alkaloid (13), and a protoberberine alkaloid (17), were isolated from the …

Two novel series of tryptanthrin (TRYP) derivatives were designed and synthesized as
multifunctional agents for the treatment of Alzheimer's disease (AD). Inhibition assay against …