As the most commonly occurring cancer in women worldwide, breast cancer poses a
formidable public health challenge on a global scale. Breast cancer consists of a group of …

Proliferation is an important part of cancer development and progression. This is manifest by
altered expression and/or activity of cell cycle related proteins. Constitutive activation of …

In recent years, it has been shown that breast cancer consists not only of neoplastic cells,
but also of significant alterations in the surrounding stroma or tumor microenvironment …

Background Breast cancer (BC), the second most common cause of cancer-related deaths,
remains a significant threat to the health and wellness of women worldwide. The tumor …

Introduction Breast cancer (BC) accounts for the majority of cancers among the female
population. Anomalous activation of various signaling pathways has become an issue of …

Drug resistance is a major problem in the treatment of cancer patients. Resistance can
develop after prolonged cycles of chemotherapy or can be present intrinsically in the patient …

Patient‑derived xenograft (PDX) mouse models involve the direct transfer of fresh human
tumor samples into immunodeficient mice following surgical resection or other medical …

Breast cancer (BC) is the leading cause of cancer death in women. This disease is
heterogeneous, with clinical subtypes being estrogen receptor-α (ER-α) positive, having …

Abstract Aim Doxorubicin/Cyclophosphamide (AC) is one of the standard adjuvant
anthracycline-containing regimens that is still in use for breast cancer treatment. Cancer cell …

Renal cell carcinoma (RCC) accounts for 90% of all kidney cancers. Due to poor diagnosis,
high resistance to the systemic therapies and the fact that most RCC cases occur …