Review on natural products databases: where to find data in 2020
M Sorokina, C Steinbeck - Journal of cheminformatics, 2020 - Springer
Natural products (NPs) have been the centre of attention of the scientific community in the
last decencies and the interest around them continues to grow incessantly. As a …
last decencies and the interest around them continues to grow incessantly. As a …
Advancing computer-aided drug discovery (CADD) by big data and data-driven machine learning modeling
Highlights•Drug discovery has been advanced to a big data era with a large amount of
public data sources available.•Ten V features (volume, velocity, variety, veracity, validity …
public data sources available.•Ten V features (volume, velocity, variety, veracity, validity …
COCONUT online: collection of open natural products database
Natural products (NPs) are small molecules produced by living organisms with potential
applications in pharmacology and other industries as many of them are bioactive. This …
applications in pharmacology and other industries as many of them are bioactive. This …
IMPPAT: A curated database of I ndian M edicinal P lants, P hytochemistry A nd T herapeutics
Phytochemicals of medicinal plants encompass a diverse chemical space for drug
discovery. India is rich with a flora of indigenous medicinal plants that have been used for …
discovery. India is rich with a flora of indigenous medicinal plants that have been used for …
Understanding the effectiveness of natural compound mixtures in cancer through their molecular mode of action
Many approaches to cancer management are often ineffective due to adverse reactions,
drug resistance, or inadequate target specificity of single anti-cancer agents. In contrast, a …
drug resistance, or inadequate target specificity of single anti-cancer agents. In contrast, a …
NPASS: natural product activity and species source database for natural product research, discovery and tool development
There has been renewed interests in the exploration of natural products (NPs) for drug
discovery, and continuous investigations of the therapeutic claims and mechanisms of …
discovery, and continuous investigations of the therapeutic claims and mechanisms of …
[HTML][HTML] Promising terpenes as SARS-CoV-2 spike receptor-binding domain (RBD) attachment inhibitors to the human ACE2 receptor: Integrated computational …
The spike protein receptor binding domain (S-RBD) is a necessary corona-viral protein for
binding and entry of coronaviruses (COVs) into the host cells. Hence, it has emerged as an …
binding and entry of coronaviruses (COVs) into the host cells. Hence, it has emerged as an …
Research advances on anticancer activities of matrine and its derivatives: An updated overview
H ur Rashid, Y Xu, Y Muhammad, L Wang… - European journal of …, 2019 - Elsevier
Cancer is the second leading cause of mortality, only overcome by cardiovascular diseases,
and has caused more than 8.7 million deaths in 2015 all over the world. This figure is …
and has caused more than 8.7 million deaths in 2015 all over the world. This figure is …
Data resources for the computer-guided discovery of bioactive natural products
Y Chen, C de Bruyn Kops… - Journal of chemical …, 2017 - ACS Publications
Natural products from plants, animals, marine life, fungi, bacteria, and other organisms are
an important resource for modern drug discovery. Their biological relevance and structural …
an important resource for modern drug discovery. Their biological relevance and structural …
Bioinformatics approaches for anti-cancer drug discovery
Drug discovery is important in cancer therapy and precision medicines. Traditional
approaches of drug discovery are mainly based on in vivo animal experiments and in vitro …
approaches of drug discovery are mainly based on in vivo animal experiments and in vitro …