Bile acids (BAs) can regulate their own metabolism and transport as well as other key
aspects of metabolic homeostasis via dedicated (nuclear and G protein-coupled) receptors …

Over the past two decades, bile acids (BAs) have become established as important
signaling molecules that enable fine-tuned inter-tissue communication from the liver, their …

It is well established that bile acids play important roles in lipid metabolism. In recent
decades, bile acids have also been shown to function as signaling molecules via interacting …

Bile acid synthesis is the most significant pathway for catabolism of cholesterol and for
maintenance of whole body cholesterol homeostasis. Bile acids are physiological …

This Review summarizes mechanistic investigations in faecal microbiota transplantation
(FMT), which has increasingly been adapted into clinical practice as treatment for …

Epithelial cells line the entire surface of the gastrointestinal tract and its accessory organs
where they primarily function in transporting digestive enzymes, nutrients, electrolytes, and …

The intestinal reclamation of bile acids is crucial for the maintenance of their enterohepatic
circulation. The majority of bile acids are actively absorbed via specific transport proteins …

Functional gastrointestinal disorders (FGIDs) have been re-named as disorders of gut-brain
interactions. These conditions are not only common in clinical practice, but also in the …

Chronic diarrhea is a common problem affecting up to 5% of the population at a given time.
Patients vary in their definition of diarrhea, citing loose stool consistency, increased …

Farnesoid X receptors (FXRs) are nuclear hormone receptors expressed in high amounts in
body tissues that participate in bilirubin metabolism including the liver, intestines, and …