Implication of gut microbiota in cardiovascular diseases

W Zhou, Y Cheng, P Zhu, MI Nasser… - Oxidative medicine …, 2020 - Wiley Online Library
Emerging evidence has identified the association between gut microbiota and various
diseases, including cardiovascular diseases (CVDs). Altered intestinal flora composition has …

Circadian rhythm and disease: Relationship, new insights, and future perspectives

AR Neves, T Albuquerque, T Quintela… - Journal of cellular …, 2022 - Wiley Online Library
The circadian system is responsible for internal functions and regulation of the organism
according to environmental cues (zeitgebers). Circadian rhythm dysregulation or …

Adaptive immunity, chronic inflammation and the clock

KJ Gray, JE Gibbs - Seminars in Immunopathology, 2022 - Springer
The adaptive arm of the immune system facilitates recognition of specific foreign pathogens
and, via the action of T and B lymphocytes, induces a fine-tuned response to target the …

BMAL1 loss in oligodendroglia contributes to abnormal myelination and sleep

D Rojo, L Dal Cengio, A Badner, S Kim, N Sakai… - Neuron, 2023 - cell.com
Myelination depends on the maintenance of oligodendrocytes that arise from
oligodendrocyte precursor cells (OPCs). We show that OPC-specific proliferation …

Multiple sclerosis: melatonin, orexin, and ceramide interact with platelet activation coagulation factors and gut-microbiome-derived butyrate in the circadian …

G Anderson, M Rodriguez, RJ Reiter - International journal of molecular …, 2019 - mdpi.com
Recent data highlight the important roles of the gut microbiome, gut permeability, and
alterations in mitochondria functioning in the pathophysiology of multiple sclerosis (MS) …

Circadian clock genes as promising therapeutic targets for autoimmune diseases

K Xiang, Z Xu, YQ Hu, YS He, GC Wu, TY Li… - Autoimmunity …, 2021 - Elsevier
Circadian rhythm is a natural, endogenous process whose physiological functions are
controlled by a set of clock genes. Disturbance of the clock genes have detrimental effects …

Circadian rhythms in adaptive immunity

P Downton, JO Early, JE Gibbs - Immunology, 2020 - Wiley Online Library
The circadian clock provides organisms with the ability to track time of day, allowing them to
predict and respond to cyclical changes in the external environment. In mammals this clock …

Circadian rhythm alterations affecting the pathology of neurodegenerative diseases

JB Canever, LY Queiroz, ES Soares… - Journal of …, 2024 - Wiley Online Library
The circadian rhythm is a nearly 24‐h oscillation found in various physiological processes in
the human brain and body that is regulated by environmental and genetic factors. It is …

Circadian rhythms and glial cells of the central nervous system

A Brécier, VW Li, CS Smith, K Halievski… - Biological …, 2023 - Wiley Online Library
Glial cells are the most abundant cells in the central nervous system and play crucial roles in
neural development, homeostasis, immunity, and conductivity. Over the past few decades …

[HTML][HTML] Rhythms in barriers and fluids: circadian clock regulation in the aging neurovascular unit

L Skapetze, S Owino, EH Lo, K Arai, M Merrow… - Neurobiology of …, 2023 - Elsevier
The neurovascular unit is where two very distinct physiological systems meet: The central
nervous system (CNS) and the blood. The permeability of the barriers separating these …