Neurofilament light chain as a biomarker in neurological disorders

L Gaetani, K Blennow, P Calabresi… - Journal of Neurology …, 2019 - jnnp.bmj.com
In the management of neurological diseases, the identification and quantification of axonal
damage could allow for the improvement of diagnostic accuracy and prognostic assessment …

Blood neurofilament light: a critical review of its application to neurologic disease

C Barro, T Chitnis, HL Weiner - Annals of clinical and …, 2020 - Wiley Online Library
Neuronal injury is a universal event that occurs in disease processes that affect both the
central and peripheral nervous systems. A blood biomarker linked to neuronal injury would …

Time course and diagnostic utility of NfL, tau, GFAP, and UCH-L1 in subacute and chronic TBI

P Shahim, A Politis, A Van Der Merwe, B Moore… - Neurology, 2020 - AAN Enterprises
Objective To determine whether neurofilament light (NfL), glial fibrillary acidic protein
(GFAP), tau, and ubiquitin C-terminal hydrolase-L1 (UCH-L1) measured in serum relate to …

The multifaceted role of neurofilament light chain protein in non-primary neurological diseases

S Abu-Rumeileh, A Abdelhak, M Foschi, L D'Anna… - Brain, 2023 - academic.oup.com
The advancing validation and exploitation of CSF and blood neurofilament light chain
protein as a biomarker of neuroaxonal damage has deeply changed the current diagnostic …

Acute evaluation of sport-related concussion and implications for the Sport Concussion Assessment Tool (SCAT6) for adults, adolescents and children: a systematic …

RJ Echemendia, JS Burma, JM Bruce… - British journal of sports …, 2023 - bjsm.bmj.com
Objectives To systematically review the scientific literature regarding the acute assessment
of sport-related concussion (SRC) and provide recommendations for improving the Sport …

Neurofilament light as a biomarker in traumatic brain injury

P Shahim, A Politis, A Van Der Merwe, B Moore… - Neurology, 2020 - AAN Enterprises
Objective To determine whether serum neurofilament light (NfL) correlates with CSF NfL,
traumatic brain injury (TBI) diagnosis, injury severity, brain volume, and diffusion tensor …

Blood biomarkers for mild traumatic brain injury: a selective review of unresolved issues

DB Hier, T Obafemi-Ajayi, MS Thimgan, GR Olbricht… - Biomarker …, 2021 - Springer
Background The use of blood biomarkers after mild traumatic brain injury (mTBI) has been
widely studied. We have identified eight unresolved issues related to the use of five …

S100B, actor and biomarker of mild traumatic brain injury

C Oris, S Kahouadji, J Durif, D Bouvier… - International Journal of …, 2023 - mdpi.com
Mild traumatic brain injury (mTBI) accounts for approximately 80% of all TBI cases and is a
growing source of morbidity and mortality worldwide. To improve the management of …

Postoperative delirium is associated with increased plasma neurofilament light

CP Casey, H Lindroth, R Mohanty, Z Farahbakhsh… - Brain, 2020 - academic.oup.com
While delirium is associated with cognitive decline and dementia, there is limited evidence
to support causality for this relationship. Clarification of how delirium may cause cognitive …

Association of plasma neurofilament light with postoperative delirium

TG Fong, SM Vasunilashorn, L Ngo… - Annals of …, 2020 - Wiley Online Library
Objective To examine the association of the plasma neuroaxonal injury markers
neurofilament light (NfL), total tau, glial fibrillary acid protein, and ubiquitin carboxyl‐terminal …