The administration of antibiotics while critical for treatment, can be accompanied by
potentially severe complications. These include toxicities associated with the drugs …

Antimicrobial resistance develops as a major problem in infectious diseases treatment.
While antibiotic resistance mechanisms are usually studied using lethal antibiotic doses …

The bacterial RadD enzyme is important for multiple genome maintenance pathways,
including RecA DNA strand exchange and RecA-independent suppression of DNA …

Indole is a molecule proposed to be involved in bacterial signaling. We find that indole
secretion is induced by sublethal tobramycin concentrations and increases persistence to …

Antibiotic resistance has become a major global issue. Understanding the molecular
mechanisms underlying microbial adaptation to antibiotics is of keen importance to fight …

DNA lesions or other barriers frequently compromise replisome progress. The SF2 helicase
RecG is a key enzyme in the processing of postreplication gaps or regressed forks in …

Bacteria often evolve antibiotic resistance through mutagenesis. However, the processes
causing the mutagenesis have not been fully resolved. Here, we find that a broad range of …

The possible active entry of aminoglycosides in bacterial cells has been debated since the
development of this antibiotic family. Here we report the identification of their active transport …

Genome maintenance is an essential process in all cells. In prokaryotes, the RadD protein is
important for survival under conditions that include DNA-damaging radiation. Precisely how …

Antibiotic resistance often generates defects in bacterial growth called fitness cost.
Understanding the causes of this cost is of paramount importance, as it is one of the main …