Over the last 50 years, the concept of stress has evolved significantly, and our
understanding of the underlying neurobiology has expanded dramatically. Rather than …

The mechanisms underlying the pathophysiology and treatment of depression and stress-
related disorders remain unclear, but studies in depressed patients and rodent models are …

Several common psychiatric and neurodegenerative diseases share epidemiologic risk;
however, whether they share pathophysiology is unclear and is the focus of our …

Hallucinations limit widespread therapeutic use of psychedelics as rapidly acting
antidepressants. Here we profiled the non-hallucinogenic lysergic acid diethylamide (LSD) …

Environmental stressors, such as childhood maltreatment, have been recognized to
contribute to the development of depression. Growing evidence suggests that epigenetic …

Depression represents a global mental health concern, and disproportionally affects women
as they are twice more likely to be diagnosed than men. In this review, we provide a …

Over the past few years, the perceived level of psychological stress has risen dramatically
across the globe due to a combination of events including the long-lasting Covid-19 …

In concert with neuropeptides and transmitters, the end products of the hypothalamus-
pituitary-adrenal (HPA) axis, the glucocorticoid hormones cortisol and corticosterone …

Depression is a common condition, but current treatments are only effective in a subset of
individuals. To identify new treatment targets, we integrated depression genome-wide …

Rationale Major depressive disorder is one of the leading global causes of disability, for
which the classic serotonergic psychedelics have recently reemerged as a potential …