Nanocrystals as a master key to deliver hydrophobic drugs via multiple administration routes
MB McGuckin, J Wang, R Ghanma, N Qin… - Journal of Controlled …, 2022 - Elsevier
The poor aqueous solubility of many approved drugs and most new chemical entities poses
a challenge to drug delivery scientists working in academic and industrial labs. Despite the …
a challenge to drug delivery scientists working in academic and industrial labs. Despite the …
Nanosuspension-based drug delivery systems for topical applications
Nanosuspensions have garnered recent attention as a promising strategy for mitigating the
bioavailability challenges of hydrophobic drugs, particularly those characterized by poor …
bioavailability challenges of hydrophobic drugs, particularly those characterized by poor …
Spray-freeze-dried inhalable composite microparticles containing nanoparticles of combinational drugs for potential treatment of lung infections caused by …
The multi-drug resistance of Pseudomonas aeruginosa is an overwhelming cause of
terminal and persistent lung infections in cystic fibrosis (CF) patients. Antimicrobial synergy …
terminal and persistent lung infections in cystic fibrosis (CF) patients. Antimicrobial synergy …
Glibenclamide–malonic acid cocrystal with an enhanced solubility and bioavailability
Objective The objective of the work is to enhance the solubility, dissolution, and
pharmacokinetic properties of glibenclamide (GLB) via cocrystallization technique …
pharmacokinetic properties of glibenclamide (GLB) via cocrystallization technique …
Spray dried inhalable ivacaftor co-amorphous microparticle formulations with leucine achieved enhanced in vitro dissolution and superior aerosol performance
J Guan, H Yuan, S Yu, S Mao, QT Zhou - International journal of …, 2022 - Elsevier
The present study aimed to develop inhalable powder formulations with both dissolution
enhancement and superior aerodynamic properties for potential pulmonary delivery of a …
enhancement and superior aerodynamic properties for potential pulmonary delivery of a …
Nanosuspensions: A New Era of Targeted Therapeutics
The rapid advancements in drug discovery are leading to the development of numerous
promising new drug entities with significant therapeutic potential, yet many of these suffer …
promising new drug entities with significant therapeutic potential, yet many of these suffer …
Potential risks and pharmacological safety features of hypoglycemic drugs
S Drogovoz, K Kalko, I Borysiuk, M Barus, V Horoshko… - 2021 - dspace.nuph.edu.ua
For the treatment of diabetes, insulin preparations, synthetic hypoglycemic agents, herbal
medicine and compulsory adherence to the diet. Oral hypoglycemic agents belong to …
medicine and compulsory adherence to the diet. Oral hypoglycemic agents belong to …
Formulation, optimization and full characterization of mirtazapine loaded aquasomes: a new technique to boost antidepressant effects
LM Hussein, AM Dawaba… - Drug Development and …, 2024 - Taylor & Francis
Abstract Objective The development of Mirtazapine (MRT)-loaded aquasomes by co-
precipitation sonication technique to boost the antidepressant potential of MRT …
precipitation sonication technique to boost the antidepressant potential of MRT …
Strategies adopted to improve bioavailability of Glibenclamide: Insights on novel delivery systems
Objectives: Diabetes mellitus (DM) is one of the most prevalent chronic diseases worldwide.
According to the statistics declared in 2020 by the World Health Organization [WHO], in the …
According to the statistics declared in 2020 by the World Health Organization [WHO], in the …
Optimizing the Current Type 2 Diabetes Antidiabetics with Nanotechnologies: Where Do We Stand?
A Abderrahmani, S Szunerits, S Dalle, R Boukherroub - 2022 - books.rsc.org
Diabetes is defined by the World Health Organization (WHO) as a fasting plasma glucose
level above or equal to 126 mgdLÀ1 (or 7.0 mmolLÀ1) or plasma glucose above or equal to …
level above or equal to 126 mgdLÀ1 (or 7.0 mmolLÀ1) or plasma glucose above or equal to …