Coumarin compounds in medicinal chemistry: some important examples from the last years

TM Pereira, DP Franco, F Vitorio… - Current topics in …, 2018 - ingentaconnect.com
Coumarins are natural products characterized as 1, 2 benzopyrones widely distributed in
plants, as well as, in many species of fungi and bacteria. Nowadays, many synthetic …

Recent advances in the synthesis of coumarin derivatives from different starting materials

M Lončarić, D Gašo-Sokač, S Jokić, M Molnar - Biomolecules, 2020 - mdpi.com
The study of coumarin dates back to 1820 when coumarin was first extracted from tonka
bean by Vogel. Compounds containing coumarin backbone are a very important group of …

Approaches for reactive oxygen species and oxidative stress quantification in epilepsy

R Olowe, S Sandouka, A Saadi, T Shekh-Ahmad - Antioxidants, 2020 - mdpi.com
Oxidative stress (OS) and excessive reactive oxygen species (ROS) production have been
implicated in many neurological pathologies, including acute seizures and epilepsy. Seizure …

Insight into the physiological and pathological roles of the aryl hydrocarbon receptor pathway in glucose homeostasis, insulin resistance, and diabetes development

TS Sayed, ZH Maayah, HA Zeidan, A Agouni… - Cellular & Molecular …, 2022 - Springer
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcriptional factor that mediates
the toxicities of several environmental pollutants. Decades of research have been carried …

Synthesis and biological properties of coumarin derivatives. A review

A Bouhaoui, M Eddahmi, M Dib, M Khouili… - …, 2021 - Wiley Online Library
Coumarin and its derivatives are widely used as scaffolds in the synthesis of new
heterocyclic systems. This review focuses on current developments in the synthesis of …

Deciphering the detailed structure–activity relationship of coumarins as Monoamine oxidase enzyme inhibitors—An updated review

VP Koyiparambath… - Chemical biology & …, 2021 - Wiley Online Library
In the last few years, Monoamine oxidase (MAO) have emerged as a target for the treatment
of many neurodegenerative diseases including anxiety, depression, Alzheimer's, and …

[HTML][HTML] Design, multistep synthesis and in-vitro antimicrobial and antioxidant screening of coumarin clubbed chalcone hybrids through molecular hybridization …

SK Konidala, V Kotra, RCSR Danduga, PK Kola… - Arabian Journal of …, 2021 - Elsevier
In the present study we designed and synthesized 26 coumarin clubbed chalcone hybrids (1–
13 and 14–26) in good yields (54.32–74.25%) and further tested for their antimicrobial and …

[HTML][HTML] Synthesis and antioxidant study of new polyphenolic hybrid-coumarins

K Pérez-Cruz, M Moncada-Basualto… - Arabian Journal of …, 2018 - Elsevier
The antioxidant capacity of hydroxylated coumarins and hydroxybenzoic acids has been
widely described. However, there is little information on the antioxidant activity when both …

Coumarin based fluorescent probe for detecting heavy metal ions

A Majhi, K Venkateswarlu, P Sasikumar‬‬‬‬ - Journal of Fluorescence, 2024 - Springer
Heavy metals such as Iron, Copper, and Zinc are micro-essential trace metal and involve
animportant biological role, but it quickly turns toxic at exceeding the permissible limit …

Polyphenolic Composition and Antioxidant Activity (ORAC, EPR and Cellular) of Different Extracts of Argylia radiata Vitroplants and Natural Roots

A Giordano, P Morales-Tapia, M Moncada-Basualto… - Molecules, 2022 - mdpi.com
Plant biochemistry studies have increased in recent years due to their potential to improve
human health. Argylia radiata is an extremophile plant with an interesting polyphenolic …