Importance Tranexamic acid (TXA) is an efficient antifibrinolytic agent; however, concerns
remain about the potential adverse effects, particularly vascular occlusive events, that may …

Enhanced Recovery After Surgery (ERAS) evidence-based protocols for perioperative care
can lead to improvements in clinical outcomes and cost savings. This article aims to present …

Background Perioperative bleeding is common in patients undergoing noncardiac surgery.
Tranexamic acid is an antifibrinolytic drug that may safely decrease such bleeding. Methods …

Guidelines Management of severe peri-operative bleeding: Guidelines from the European
Society of Anaesthesiology and Intensive Care

Owing to the constantly evolving nature of the medical literature, the Society of Thoracic
Surgeons (STS) clinical practice guidelines periodically undergoes evaluation and updating …

Background Tranexamic acid reduces surgical bleeding and reduces death due to bleeding
in patients with trauma. Meta-analyses of small trials show that tranexamic acid might …

Background Post-partum haemorrhage is the leading cause of maternal death worldwide.
Early administration of tranexamic acid reduces deaths due to bleeding in trauma patients …

Background Prophylactic administration of tranexamic acid has been associated with
reduced postpartum blood loss after cesarean delivery in several small trials, but evidence …

Background Tranexamic acid (TXA) reduces surgical bleeding and reduces death from
bleeding after trauma and childbirth. However, its effects on thrombotic events and seizures …

Document Reviewers: Moritz WV Wyler von Ballmoos (USA), Mate Petricevic (Croatia), Arie
Pieter Kappetein (Netherlands), Miguel Sousa-Uva (Portugal), Georg Trummer (Germany) …