The initial discovery that ob/ob mice become obese because of a recessive mutation of the
leptin gene has been crucial to discover the melanocortin pathway to control appetite. In the …

The dysfunction of melanocortin signaling has been associated with obesity, given the
important role in the regulation of energy homeostasis, food intake, satiety and body weight …

The melanocortins are derived from proopiomelanocortin (POMC) and include three forms of
melanocyte-stimulating hormone (α-, β-, γ-, MSH) and adrenocorticotropic hormone. α-MSH …

The central melanocortin system is fundamentally important for controlling food intake and
energy homeostasis. Melanocortin‐3 receptor (MC3R) is one of two major receptors of the …

Inactivating mutations in the melanocortin 3 receptor (Mc3r) have been described as
causing obesity in mice, but the physiologic effects of MC3R mutations in humans have …

Melanocortin neurons conserve body mass in hyper-or hypo-caloric conditions by conveying
signals from nutrient sensors into areas of the brain governing appetite and metabolism. In …

Understanding the complex action mechanism of appetite regulation peptides can
significantly impact therapeutic options in the treatment of obesity and other metabolic …

The mesolimbic dopamine system is the primary neural circuit mediating motivation,
reinforcement, and reward-related behavior. The activity of this system and multiple …

Background There is an urgent need to identify factors that increase vulnerability to opioid
addiction to help stem the opioid epidemic and develop more efficient …

Increasing evidence indicates that the melanocortin and mesolimbic dopamine (DA)
systems interact to regulate feeding and body weight. Because melanocortin-3 receptors …