[HTML][HTML] Breakthrough advances enhancing care in ATTR amyloid cardiomyopathy

A Porcari, G Sinagra, JD Gillmore, M Fontana… - European Journal of …, 2024 - Elsevier
Transthyretin amyloid cardiomyopathy (ATTR-CM) has been traditionally considered a rare
and inexorably fatal condition. ATTR-CM now is an increasingly recognized cause of heart …

Current and evolving multimodality cardiac imaging in managing transthyretin amyloid cardiomyopathy

L Alwan, DC Benz, SAM Cuddy, S Dobner, I Shiri… - Cardiovascular …, 2024 - jacc.org
Amyloid transthyretin (ATTR) amyloidosis is a protein-misfolding disease characterized by
fibril accumulation in the extracellular space that can result in local tissue disruption and …

Clinical and prognostic implications of right ventricular uptake on bone scintigraphy in transthyretin amyloid cardiomyopathy

A Porcari, M Fontana, M Canepa, E Biagini, F Cappelli… - Circulation, 2024 - Am Heart Assoc
BACKGROUND: The extent of myocardial bone tracer uptake with technetium
pyrophosphate, hydroxymethylene diphosphonate, and 3, 3-diphosphono-1, 2 …

SGLT2 inhibitor therapy in patients with transthyretin amyloid cardiomyopathy

A Porcari, F Cappelli, C Nitsche, D Tomasoni… - Journal of the American …, 2024 - jacc.org
Abstract Background Transthyretin cardiomyopathy (ATTR-CM) was an exclusion criterion in
randomized clinical trials of sodium-glucose cotransporter 2 inhibitors (SGLT2i). Objectives …

[HTML][HTML] Safety review of therapeutic ultrasound for spinal cord neuromodulation and blood–spinal cord barrier opening

R Xu, BE Treeby, E Martin - Ultrasound in medicine & biology, 2024 - Elsevier
New focused ultrasound spinal cord applications have emerged, particularly those
improving therapeutic agent delivery to the spinal cord via blood–spinal cord barrier …

Renal AL Amyloidosis: Updates on Diagnosis, Staging, and Management

A Shafqat, H Elmaleh, A Mushtaq, Z Firdous… - Journal of Clinical …, 2024 - mdpi.com
AL amyloidosis is caused by the excessive production of nonfunctional immunoglobulins,
leading to the formation of amyloid fibrils that damage vital organs, especially the heart and …

Histological Typing in Patients With Cardiac Amyloidosis: JACC Review Topic of the Week

E Gonzalez-Lopez, ED McPhail, C Salas-Anton… - Journal of the American …, 2024 - jacc.org
Cardiac amyloidosis is increasingly recognized as a treatable form of heart failure. Highly
effective specific therapies have recently become available for the 2 most frequent forms of …

Impact of the noninvasive diagnostic algorithm on clinical presentation and prognosis in cardiac amyloidosis

G Tini, E Cristiano, M Zampieri, A Ponziani, A Porcari… - JACC: Advances, 2024 - jacc.org
Background The introduction of a noninvasive diagnostic algorithm in 2016 led to increased
awareness and recognition of cardiac amyloidosis (CA). Objectives The purpose of this …

Diagnostic modalities and radiopharmaceuticals with particular importance of technetium-99m (99mTc)

N Ahmed, M Zia - Chinese Journal of Academic Radiology, 2023 - Springer
With the emergence of new diseases, a lot of advancements have been made in diagnosis
such as identification of new biomarkers, imaging techniques, radioisotopes tracking, and …

Quantitative SPECT/CT parameters in the assessment of transthyretin cardiac amyloidosis—a new dimension of molecular imaging

M Gherghe, AM Lazar, MC Sterea, PM Spiridon… - Journal of …, 2023 - mdpi.com
Aims: Cardiac transthyretin amyloidosis (ATTR) represents the accumulation of misfolded
transthyretin in the heart interstitium. Planar scintigraphy with bone-seeking tracers has long …