Tumour progression is modulated by the local microenvironment. This environment is
populated by many immune cells, of which macrophages are among the most abundant …

The cascade of metastasis in tumor cells, exhibiting organ-specific tendencies, may occur at
numerous phases of the disease and progress under intense evolutionary pressures. Organ …

Tumor-associated myeloid cells (TAMCs) are among the most important immune cell
populations in the tumor microenvironment, and play a significant role on the efficacy of …

Alternatively activated macrophage (M2) polarization can result in one of four subtypes
based on cytokines and signaling pathways associated with macrophage activation: M2a …

Accumulating evidence has demonstrated the involvement of B cells in neuroinflammation
and neuroregeneration. However, the role of B cells in ischemic stroke remains unclear. In …

The colony-stimulating factor 1 receptor (CSF-1R) plays a pivotal role in orchestrating
cellular interactions within the tumor microenvironment (TME). Although the CSF-1R has …

Metastasis is the leading cause of cancer mortality. Functional and clinical studies have
documented diverse B-cell and antibody responses in cancer metastasis. The presence of B …

Simple Summary The development of targeted therapies has led to personalized medicine
for advanced non-small cell lung cancer (NSCLC), particularly in lung adenocarcinoma …

Metastasis is an important cause of cancer-related death. Immunotherapy may be an
effective way to prevent and treat tumor metastasis in the future. Currently, many studies …

Understanding the dynamic tumor immune microenvironment (TIME) is important in guiding
immunotherapy. We have previously validated signatures predictive of checkpoint inhibitor …