Clinical development of bromodomain and extra‐terminal (BET) protein inhibitors differs
from the traditional course of drug development. These drugs are simultaneously being …

Cofactor squelching is the term used to describe competition between transcription factors
(TFs) for a limited amount of cofactors in a cell with the functional consequence that TFs in a …

Brown adipocytes regulate energy expenditure via mitochondrial uncoupling. This makes
these fat cells attractive therapeutic targets to tackle the burgeoning issue of obesity, which …

Brown and brown-like adipocytes are specialized adipocytes with a high capacity to convert
metabolic energy to heat. This function is not only eminent in supporting organismal …

The glucocorticoid receptor (NR3C1, also known as GR) binds to specific DNA sequences
and directly induces transcription of anti-inflammatory genes that contribute to cytokine …

Obesity is a chronic disease characterized by increased adipose tissue due to either an
increase in the size (hypertrophy) and/or number of adipocytes (hyperplasia). Hyperplasia is …

目的: 观察乌地那非对3T3-L1 脂肪细胞分化和脂联素生成与分泌的影响, 探讨其可能的机制.
方法: 实验分对照组, 5 μmol/L 乌地那非处理组, 10 μmol/L 乌地那非处理组, 20 μmol/L …