Avidity in antibody effector functions and biotherapeutic drug design
SC Oostindie, GA Lazar, J Schuurman… - Nature Reviews Drug …, 2022 - nature.com
Antibodies are the cardinal effector molecules of the immune system and are being
leveraged with enormous success as biotherapeutic drugs. A key part of the adaptive …
leveraged with enormous success as biotherapeutic drugs. A key part of the adaptive …
Antibodies to SARS-CoV-2 and their potential for therapeutic passive immunization
PJ Klasse, JP Moore - Elife, 2020 - elifesciences.org
We review aspects of the antibody response to SARS-CoV-2, the causative agent of the
COVID-19 pandemic. The topics we cover are relevant to immunotherapy with plasma from …
COVID-19 pandemic. The topics we cover are relevant to immunotherapy with plasma from …
[HTML][HTML] Complete mapping of mutations to the SARS-CoV-2 spike receptor-binding domain that escape antibody recognition
Antibodies targeting the SARS-CoV-2 spike receptor-binding domain (RBD) are being
developed as therapeutics and are a major contributor to neutralizing antibody responses …
developed as therapeutics and are a major contributor to neutralizing antibody responses …
Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody
The recurrent zoonotic spillover of coronaviruses (CoVs) into the human population
underscores the need for broadly active countermeasures. We employed a directed …
underscores the need for broadly active countermeasures. We employed a directed …
[HTML][HTML] Why is there low morbidity and mortality of COVID-19 in Africa?
Three months since the detection of the first COVID-19 case in Africa, almost all countries of
the continent continued to report lower morbidity and mortality than the global trend …
the continent continued to report lower morbidity and mortality than the global trend …
Protective neutralizing antibodies from human survivors of Crimean-Congo hemorrhagic fever
JM Fels, DP Maurer, AS Herbert, AS Wirchnianski… - Cell, 2021 - cell.com
Crimean-Congo hemorrhagic fever virus (CCHFV) is a World Health Organization priority
pathogen. CCHFV infections cause a highly lethal hemorrhagic fever for which specific …
pathogen. CCHFV infections cause a highly lethal hemorrhagic fever for which specific …
A combination of receptor-binding domain and N-terminal domain neutralizing antibodies limits the generation of SARS-CoV-2 spike neutralization-escape mutants
D Haslwanter, ME Dieterle, AZ Wec, CM O'brien… - Mbio, 2021 - Am Soc Microbiol
Most known SARS-CoV-2 neutralizing antibodies (nAbs), including those approved by the
FDA for emergency use, inhibit viral infection by targeting the receptor-binding domain …
FDA for emergency use, inhibit viral infection by targeting the receptor-binding domain …
Analysis of a therapeutic antibody cocktail reveals determinants for cooperative and broad ebolavirus neutralization
Structural principles underlying the composition of protective antiviral monoclonal antibody
(mAb) cocktails are poorly defined. Here, we exploited antibody cooperativity to develop a …
(mAb) cocktails are poorly defined. Here, we exploited antibody cooperativity to develop a …
A two-antibody pan-ebolavirus cocktail confers broad therapeutic protection in ferrets and nonhuman primates
Recent and ongoing outbreaks of Ebola virus disease (EVD) underscore the unpredictable
nature of ebolavirus reemergence and the urgent need for antiviral treatments …
nature of ebolavirus reemergence and the urgent need for antiviral treatments …
Broadly neutralizing antibody cocktails targeting Nipah virus and Hendra virus fusion glycoproteins
Abstract Hendra virus (HeV) and Nipah virus (NiV) are henipaviruses (HNVs) causing
respiratory illness and severe encephalitis in humans, with fatality rates of 50–100%. There …
respiratory illness and severe encephalitis in humans, with fatality rates of 50–100%. There …