3D gastruloids, aggregates of embryonic stem cells that recapitulate key aspects of gastrula-
stage embryos, have emerged as a powerful tool to study the early stages of mammalian …

The body plan of the mammalian embryo is shaped through the process of gastrulation, an
early developmental event that transforms an isotropic group of cells into an ensemble of …

Pharmaceuticals intended for use in patients of childbearing potential need to be tested for
teratogenicity before marketing. Several pharmaceutical companies use animal-free in vitro …

Background: Recapitulating mammalian cell type differentiation in vitro promises to improve
our understanding of how these processes happen in vivo, while bringing additional …

Many amniote vertebrate species including humans can form identical twins from a single
embryo, but this only occurs rarely. It has been suggested that the primitive-streak-forming …

Background: Recapitulating mammalian cell type differentiation in vitro promises to improve
our understanding of how these processes happen in vivo, while bringing additional …

Multipotent, migratory progenitors neural crest cells (NCC) and their multipotent derivatives,
peripheral-nerve-associated Schwann cell precursors (SCP), contribute to a diverse …