The persistence of increased excitability and spontaneous activity in injured peripheral
neurons is imperative for the development and persistence of many forms of neuropathic …

The transient receptor potential melastatin subtype 8 (TRPM8) is a cold sensor in humans,
activated by low temperatures (> 10,< 28° C), but also a polymodal ion channel, stimulated …

Pain is a common symptom induced during envenomation by spiders and scorpions. Toxins
isolated from their venom have become essential tools for studying the functioning and …

This report describes methodological and exploratory investigations of the zymosan-induced
neonatal bladder inflammation (NBI) model of interstitial cystitis/bladder pain syndrome …

Patients with systemic lupus erythematosus (SLE) often suffer from chronic pain. Little is
known about the peripheral mechanisms underlying the genesis of chronic pain induced by …

Orofacial pain (OFP) is a dental specialty that includes the diagnosis, management and
treatment of disorders of the jaw, mouth, face, head and neck. Evidence-based …

This review highlights potential molecular targets for treating neuropathic orofacial pain
based on current findings in animal models. Preclinical research is currently elucidating the …

Cold sensation is initiated in the periphery by a specialized population of cold-sensitive
neurons, referred to as cold receptors, who transmit decreases in temperature with sub …

Neuropathic pain arises from damage or disorders affecting the somatosensory system. In
rats, L5 nerve injury induces thermal and mechanical hypersensitivity/hyperalgesia …

Chronic pain arising from peripheral nerve injuries represents a significant clinical challenge
because even the most efficacious anticonvulsant drug treatments are limited by their side …