Enhancers are central for the regulation of metazoan transcription but have proven difficult to
study, primarily due to a myriad of interdependent variables shaping their activity …

DNA supercoiling is central to many fundamental processes of living organisms. Its average
level along the chromosome and over time reflects the dynamic equilibrium of opposite …

Transcription has a mechanical component, as the translocation of the transcription
machinery or RNA polymerase (RNAP) on DNA or chromatin is dynamically coupled to the …

This study aims to explore whether and how positive and negative supercoiling contribute to
the three-dimensional (3D) organization of the bacterial genome. We used recently …

Transcription is a noisy and stochastic process that produces sibling‐to‐sibling variations in
physiology across a population of genetically identical cells. This pattern of diversity reflects …

Transcription has a mechanical component, as the translocation of the transcription
machinery or RNA polymerase (RNAP) on DNA or chromatin is dynamically coupled to the …

All biological processes ultimately come from physical interactions. The mechanical
properties of DNA play a critical role in transcription. RNA polymerase can over or under …

Stochastic simulation models have played an important role in efforts to understand the
mechanistic basis of prokaryotic transcription and translation. Despite the fundamental …

One of the biggest paradoxes in biology is that human genome is roughly 2 m long, while
the nucleus containing it is almost one million times smaller. To fit into the nucleus, DNA …

Gene syntax—the order and arrangement of genes and their regulatory elements—shapes
the dynamic coordination of both natural and synthetic gene circuits. Transcription at one …