Proteases are signaling molecules that specifically control cellular functions by cleaving
protease-activated receptors (PARs). The four known PARs are members of the large family …

October 1, 1905 (1). Today, after more than 100 years and 350,000 articles on these
enzymes in the scientific literature, proteases remain at the cutting edge of biological …

G protein-coupled receptors (GPCRs) are the largest family of membrane-bound receptors
and also the targets of many drugs. Understanding of the functional significance of the wide …

Proteinase-activated receptors (PARs) are a subfamily of G protein-coupled receptors
(GPCRs) with four members, PAR 1, PAR 2, PAR 3 and PAR 4, playing critical functions in …

Human tissue kallikreins are a family of 15 trypsin‐or chymotrypsin‐like secreted serine
proteases (KLK1–KLK15). Many KLKs have been identified in normal stratum corneum (SC) …

Objectives Proteases are key mediators of pain and altered enteric neuronal signalling,
although the types and sources of these important intestinal mediators are unknown. We …

The human tissue kallikrein and kallikrein-related peptidases (KLKs), encoded by the largest
contiguous cluster of protease genes in the human genome, are secreted serine proteases …

Matrix metalloproteinases (MMPs) are implicated in the degradation of extracellular matrix
(ECM). Rheumatoid arthritis (RA) synovial fibroblasts (SFs) produce matrix-degrading …

Recently, we described phorbol ester–induced expression of the brain and skin serine
proteinase Bssp/kallikrein 6 (Klk6), the mouse orthologue of human KLK6, in mouse back …

Despite the widespread use of conventional and contemporary methods to detect ovarian
cancer development, ovarian cancer remains a common and commonly fatal gynecological …