Tumor necrosis factor (TNF) plays a central role in orchestrating mammalian inflammatory
responses. It promotes inflammation either directly by inducing inflammatory gene …

Abstract Receptor-interacting protein 1 (RIP1) kinase has emerged as a key upstream
regulator that controls inflammatory signalling as well as the activation of multiple cell death …

RIPK3 and its substrate MLKL are essential for necroptosis, a lytic cell death proposed to
cause inflammation via the release of intracellular molecules. Whether and how RIPK3 …

Ubiquitination is one of the most important post‐translational modifications which plays a
significant role in conserving the homeostasis of cellular proteins. In the ubiquitination …

X-linked inhibitor of apoptosis protein (XIAP) has been identified as a potent regulator of
innate immune responses, and loss-of-function mutations in XIAP cause the development of …

RIP1 kinase, a multifunctional protein that contains an N-terminal Ser/Thr kinase and a C-
terminal death domain, has emerged as a key regulatory molecule involved in regulating …

Apoptosis is a tightly regulated cellular process and faulty regulation of apoptosis is a
hallmark of human cancers. Targeting key apoptosis regulators with the goal to restore …

Cell death has a fundamental impact on the evolution of degenerative disorders,
autoimmune processes, inflammatory diseases, tumor formation and immune surveillance …

Despite recent advances in our understanding of the disease, glioblastoma (GB) continues
to have limited treatment options and carries a dismal prognosis for patients. Efforts to stratify …

Abstract Inhibitors of Apoptosis (IAPs) are a family of proteins with various biological
functions including regulation of innate immunity and inflammation, cell proliferation, cell …