Transmissible spongiform encephalopathies (TSEs) are neurodegenerative diseases that
are caused by prions and affect humans and many animal species. It is now widely accepted …

Prion diseases are transmissible, invariably fatal, neurodegenerative diseases which
include Creutzfeldt–Jakob disease (CJD) in humans and bovine spongiform …

Three decades after the discovery of prions as the cause of Creutzfeldt-Jakob disease and
other transmissible spongiform encephalopathies, we are still nowhere close to finding an …

Prion diseases are fatal transmissible neurodegenerative diseases, characterized by
aggregation of the pathological form of prion protein, spongiform degeneration, and …

Inflammasomes are an essential part of the innate immune system. They are necessary for
the development of a healthy immune response against infectious diseases. Inflammasome …

Prion diseases are fatal infectious neurodegenerative disorders and prototypic
conformational diseases, caused by the conformational conversion of the normal cellular …

The absence of a detectable immune response during transmissible spongiform
encephalopathies is likely due to the fact that the essential component of infectious agents …

Infectious prions comprising abnormal prion protein, which is produced by structural
conversion of normal prion protein, are responsible for transmissible spongiform …

In the last two decades, knowledge of the neurobiology of prion diseases or transmissible
spongiform encephalopathies (TSE) has significantly advanced, but a successful therapy to …

Prion diseases such as scrapie involve the accumulation of disease-specific prion protein,
PrPSc, in the brain. Toll-like receptors (TLRs) are a family of proteins that recognize …