Vascular dysfunction in preeclampsia

MA Opichka, MW Rappelt, DD Gutterman, JL Grobe… - Cells, 2021 - mdpi.com
Preeclampsia is a life-threatening pregnancy-associated cardiovascular disorder
characterized by hypertension and proteinuria at 20 weeks of gestation. Though its exact …

Preeclampsia beyond pregnancy: long-term consequences for mother and child

HR Turbeville, JM Sasser - American Journal of Physiology …, 2020 - journals.physiology.org
Preeclampsia is defined as new-onset hypertension after the 20th wk of gestation along with
evidence of maternal organ failure. Rates of preeclampsia have steadily increased over the …

The angiotensin AT2 receptor: from a binding site to a novel therapeutic target

UM Steckelings, RE Widdop, ED Sturrock… - Pharmacological …, 2022 - Elsevier
Discovered more than 30 years ago, the angiotensin AT 2 receptor (AT 2 R) has evolved
from a binding site with unknown function to a firmly established major effector within the …

Cardiovascular system in preeclampsia and beyond

B Thilaganathan, E Kalafat - Hypertension, 2019 - Am Heart Assoc
Thilaganathan and Kalafat Cardiovascular System in Preeclampsia and Beyond 523 age of
60 years have an increased risk of preeclampsia. 18, 31 Previous preeclampsia is a risk …

Long-term impacts of preeclampsia on the cardiovascular system of mother and offspring

C Yang, PN Baker, JP Granger, ST Davidge… - Hypertension, 2023 - Am Heart Assoc
Preeclampsia is a pregnancy-specific complication that is associated with an increased
postpartum risk of cardiovascular disease (CVD) in both women and their offspring, although …

Sex differences in risk factors for vascular contributions to cognitive impairment & dementia

OJ Gannon, LS Robison, AJ Custozzo… - Neurochemistry …, 2019 - Elsevier
Vascular contributions to cognitive impairment and dementia (VCID) is the second most
common cause of dementia. While males overall appear to be at a slightly higher risk for …

[HTML][HTML] Preeclampsia: linking placental ischemia with maternal endothelial and vascular dysfunction

BA Bakrania, FT Spradley, HA Drummond… - Comprehensive …, 2020 - ncbi.nlm.nih.gov
Preeclampsia (PE), a hypertensive disorder, occurs in 3% to 8% of pregnancies in the
United States and affects over 200,000 women and newborns per year. The United States …

Association of hypertensive disorders of pregnancy with left ventricular remodeling later in life

ME Countouris, FS Villanueva, KL Berlacher… - Journal of the American …, 2021 - jacc.org
Background Hypertensive disorders of pregnancy (HDP) are associated with short-term
cardiac structure and function abnormalities, but later life changes are not well studied …

Inflammation, depression and cardiovascular disease in women: the role of the immune system across critical reproductive events

GF Mattina, RJ Van Lieshout… - Therapeutic advances in …, 2019 - journals.sagepub.com
Women are at increased risk for developing depression and cardiovascular disease (CVD)
across the lifespan and their comorbidity is associated with adverse outcomes that …

Oxidative stress contributes to microvascular endothelial dysfunction in men and women with major depressive disorder

JL Greaney, EFH Saunders, L Santhanam… - Circulation …, 2019 - Am Heart Assoc
Rationale: In rodent models of depression, oxidative stress-induced reductions in NO
bioavailability contribute to impaired endothelium-dependent dilation. Endothelial …