Over the past few decades, the advent of C–H activation has led to a rethink among
chemists about the synthetic strategies employed for multi-step transformations. Indeed …

In the field of C–H bond functionalization chemistry, directed C–H bond activation strategies
are highly appreciated due to the high efficiency and selectivity of such reactions towards a …

Organic reactions that involve the direct functionalization of non-activated C–H bonds
represent an attractive class of transformations which maximize atom-and step-economy …

The atomistic change of C (sp3)–H to C (sp3)–O can have a profound impact on the physical
and biological properties of small molecules. Traditionally, chemical synthesis has relied on …

The direct functionalization of C H bonds in organic compounds has recently emerged as a
powerful and ideal method for the formation of carbon–carbon and carbon–heteroatom …

Inspired by the need for green and sustainable chemistry,(1) synthetic chemists seek more
efficient ways to construct carbon− carbon (C− C) bonds, the essential link in all organic …

Functionalizing traditionally inert carbon–hydrogen bonds represents a powerful
transformation in organic synthesis, providing new entries to valuable structural motifs and …

Metal-catalysed C–H bond functionalisation has had a significant impact on how chemists
make molecules. Translating the methodological developments to their use in the assembly …

In this critical review, the strategic and economic benefits of C–H functionalization logic will
be analyzed through the critical lens of total synthesis. In order to illustrate the dramatically …

Transition‐metal‐catalyzed C H activation has recently emerged as a powerful tool for the
functionalization of organic molecules. While many efforts have focused on the …