Lung cancer has a high prevalence, with a growing number of new cases and mortality
every year. Furthermore, the survival rate of patients with non-small-cell lung carcinoma …

Current studies related to lipid identification and determination, or lipidomics in biological
samples, are one of the most important issues in modern bioanalytical chemistry. There are …

Abstract CD47, a “don't eat me” signal, is over-expressed on the surface of most tumors that
interacts with signal regulatory protein α (SIRPα) on phagocytic cells. By engaging SIRPα …

Conspectus The structures of membrane-bound polypeptides are intimately related to their
functions and may change dramatically with the lipid environment. Circular dichroism (CD) is …

The epidermal growth factor receptor (EGFR) is a dimeric membrane protein that regulates
key aspects of cellular function. Activation of the EGFR is linked to changes in the …

Interaction between transmembrane helices often determines biological activity of
membrane proteins. Bitopic proteins, a broad subclass of membrane proteins, form dimers …

The interaction of membranes with peptides and proteins is largely determined by their
amphiphilic character. Hydrophobic moments of helical segments are commonly derived …

Intercellular interactions form the cornerstone of multicellular biology. Despite advances in
protein engineering, researchers artificially directing physical cell interactions still rely on …

Blinding diseases that are caused by degeneration of rod and cone photoreceptor cells
often spare the rest of the retinal circuit, from bipolar cells, which are directly innervated by …

Intracellular signalling cascades initiated by class III receptor tyrosine kinases (RTK-IIIs) and
their cytokine ligands contribute to haematopoiesis and mesenchymal tissue development …