Atherosclerotic disease, such as myocardial infarction and stroke, is the number one killer
worldwide. Atherosclerosis is considered to be caused by multiple factors, including genetic …

Coronary artery disease is the leading global cause of mortality. Long recognized to be
heritable, recent advances have started to unravel the genetic architecture of the disease …

The microbes and microbial pathways that influence host inflammatory disease progression
remain largely undefined. Here, we show that variation in atherosclerosis burden is partially …

Most of the biological understanding of mechanisms underlying coronary artery disease
(CAD) derives from studies of mouse models. The identification of multiple CAD loci and …

Rationale: Atherosclerosis can be achieved in animals by germline genetic engineering,
leading to hypercholesterolemia, but such models are constrained to few species and …

Background—Epigenetic alterations may contribute to the development of atherosclerosis.
In particular, DNA methylation, a reversible and highly regulated DNA modification, could …

Murine models of atherosclerosis are useful for investigating the environmental and genetic
influences on lesion formation and composition. Apoe−/− and Ldlr−/− mice are the 2 most …

Common forms of atherosclerosis involve multiple genetic and environmental factors. While
human genome-wide association studies have identified numerous loci contributing to …

Background A deeper understanding of differences and similarities in transcriptional
regulation between species can uncover important information about gene functions and the …

Mechanistic understanding of atherosclerosis is largely hampered by the lack of a suitable in
vitro human arterial model that recapitulates the arterial wall structure, and the interplay …