Photocatalytic late-stage C–H functionalization

P Bellotti, HM Huang, T Faber, F Glorius - Chemical Reviews, 2023 - ACS Publications
The emergence of modern photocatalysis, characterized by mildness and selectivity, has
significantly spurred innovative late-stage C–H functionalization approaches that make use …

Direct photocatalyzed hydrogen atom transfer (HAT) for aliphatic C–H bonds elaboration

L Capaldo, D Ravelli, M Fagnoni - Chemical Reviews, 2021 - ACS Publications
Direct photocatalyzed hydrogen atom transfer (d-HAT) can be considered a method of
choice for the elaboration of aliphatic C–H bonds. In this manifold, a photocatalyst (PCHAT) …

Photoelectrochemical asymmetric catalysis enables site-and enantioselective cyanation of benzylic C–H bonds

CY Cai, XL Lai, Y Wang, HH Hu, J Song, Y Yang… - Nature Catalysis, 2022 - nature.com
The enantioselective functionalization of ubiquitous C (sp 3)–H bonds is ideally suited for
the construction of three-dimensional chiral structures. However, organic molecules often …

Strategies to generate nitrogen-centered radicals that may rely on photoredox catalysis: development in reaction methodology and applications in organic synthesis

K Kwon, RT Simons, M Nandakumar… - Chemical …, 2021 - ACS Publications
For more than 70 years, nitrogen-centered radicals have been recognized as potent
synthetic intermediates. This review is a survey designed for use by chemists engaged in …

Radical C(sp3)–H functionalization and cross-coupling reactions

DL Golden, SE Suh, SS Stahl - Nature Reviews Chemistry, 2022 - nature.com
C–H functionalization reactions are playing an increasing role in the preparation and
modification of complex organic molecules, including pharmaceuticals, agrochemicals and …

N-Functionalized Pyridinium Salts: A New Chapter for Site-Selective Pyridine C–H Functionalization via Radical-Based Processes under Visible Light Irradiation

M Kim, Y Koo, S Hong - Accounts of Chemical Research, 2022 - ACS Publications
Conspectus The radical-mediated C–H functionalization of pyridines has attracted
considerable attention as a powerful tool in synthetic chemistry for the direct …

Resurgence and advancement of photochemical hydrogen atom transfer processes in selective alkane functionalizations

L Chang, S Wang, Q An, L Liu, H Wang, Y Li… - Chemical …, 2023 - pubs.rsc.org
The selective functionalization of alkanes has long been recognized as a prominent
challenge and an arduous task in organic synthesis. Hydrogen atom transfer (HAT) …

Diboron (4)‐catalyzed remote [3+ 2] cycloaddition of cyclopropanes via dearomative/rearomative radical transmission through pyridine

M Xu, Z Wang, Z Sun, Y Ouyang, Z Ding… - Angewandte …, 2022 - Wiley Online Library
Ring structures such as pyridine, cyclopentane or their combinations are important motifs in
bioactive molecules. In contrast to previous cycloaddition reactions that necessitated a …

C–H Functionalization of Pyridines via Oxazino Pyridine Intermediates: Switching to para-Selectivity under Acidic Conditions

H Cao, D Bhattacharya, Q Cheng… - Journal of the American …, 2023 - ACS Publications
para-Selective C–H functionalization of pyridines holds a significant value but remains
underdeveloped. Site-switchable C–H functionalization of pyridines under easily tunable …

Aliphatic C–H Functionalization Using Pyridine N-Oxides as H-Atom Abstraction Agents

M Schlegel, S Qian, DA Nicewicz - ACS catalysis, 2022 - ACS Publications
The alkylation and heteroarylation of unactivated tertiary, secondary, and primary C (sp3)–H
bonds was achieved by employing an acridinium photoredox catalyst along with readily …