Although skeletal muscle repairs itself following small injuries, genetic diseases or severe
damages may hamper its ability to do so. Induced pluripotent stem cells (iPSCs) can …

Muscular dystrophies and congenital myopathies arise from specific genetic mutations
causing skeletal muscle weakness that reduces quality of life. Muscle health relies on …

Skeletal muscle repair is driven by the coordinated self-renewal and fusion of myogenic
stem and progenitor cells. Single-cell gene expression analyses of myogenesis have been …

Skeletal muscles support the stability and mobility of the skeleton but differ in biomechanical
properties and physiological functions. The intrinsic factors that regulate muscle-specific …

Cerebral palsy (CP), the single largest cause of childhood physical disability, is
characterized firstly by a lesion in the immature brain, and secondly by musculoskeletal …

The generation of myogenic progenitors from iPSCs (iMPs) with therapeutic potential for in
vivo tissue regeneration has long been a goal in the skeletal muscle community. Today …

Human pluripotent stem cells (PSCs), which have the capacity to self-renew and differentiate
into multiple cell types, offer tremendous therapeutic potential and invaluable flexibility as …

Skeletal muscle repair is driven by the coordinated self-renewal and fusion of myogenic
stem and progenitor cells. Single-cell gene expression analyses of myogenesis have been …

Sarcopenia is a progressive loss of muscle mass and function that is connected with
increased hospital expenditures, falls, fractures, and mortality. Although muscle loss has …

Human pluripotent stem cells (hPSCs) provide a human model for developmental
myogenesis, disease modeling and development of therapeutics. Differentiation of hPSCs …